http://www.theherald.co.uk/news/archive/4-8-1999-23-3-46.html Cancer test on sweetner CHRIS STARRS RESEARCH is to be carried out to discover whether there are possible links between an artificial sweetener used in some of the most popular low-sugar drinks and brain cancer. The three-year project will study aspartame, marketed under the name NutraSweet. Scientists at King's College, London, will investigate whether aspartame, which is 200 times sweeter than normal sugar and is used in many low-calorie and non-calorie drinks, could be linked to an increased risk of primary brain tumours. The study will look at whether people with certain genetic make-ups are susceptible to methanol, a compound in aspartame which some research has suggested can attack DNA and cause cells to mutate and cause cancer. Neurochemist Dr Peter Nunn, who is heading the study, said: "Primary brain tumours are of considerable interest to everybody because the cause of them is not known. "Some studies have shown there to be a link between aspartame and primary brain tumours, and some studies have shown there to be no link. "This study does not set out to rubbish aspartame. It is a serious study into whether people with certain genes are more susceptible to these compounds than others." The research will not involve experiments on humans or animals but will look at whether cells of certain tumours react to chemicals. NutraSweet welcomed the study and said there was "overwhelming scientific evidence" to prove the product was safe. In a statement it said: "There is already an overwhelming amount of scientific evidence which confirms the safety of aspartame, but scare- mongerers have continued to claim that aspartame is linked to brain tumours. "We have no doubt whatsoever that provided the study is well-designed and well-conducted, it will show that there is no such link. The study will therefore provide a further opportunity to put these groundless rumours to rest. "It is physiologically impossible for aspartame to cause brain tumours because it never enters the bloodstream and thus cannot travel to essential organs, including the brain." Aspartame was invented in 1965 but has taken hold in Britain only in the last decade. The study is being funded by a £147,000 grant from the Samantha Dickson Research Trust with the help of cash from the lottery. The trust was set up by Angela and Neil Dickson after their daughter Samantha died from a brain tumour six days before her 17th birthday in 1996. Mrs Dickson, of Hook, Hampshire, said: "We are funding six projects to try to find a cure for brain tumours. "This particular project has nothing to do with the way Samantha died. We asked for applications for research projects and this was one of them. "We don't know if there is a link (between aspartame and brain cancer) but this project will help us to find out about it." The research follows the publication of a controversial book, Excitotoxins: The Taste that Kills, by US neurosurgeon Russell Blaylock, which claimed aspartame was toxic to brain tissue. It said that an aspartame molecule was made of three components: phenylalanine, aspartic acid and methanol (wood alcohol). For every molecule of aspartame metabolised, a molecule of methanol was released into the bloodstream. Methanol is present in fruit and fruit juices and especially in alcoholic beverages. But in these foods the methanol is accompanied by larger amounts of ethanol which slows down its metabolism, allowing much of it to be excreted in the breath and urine. In most aspartame-sweetened beverages there was no accompanying ethanol, Dr Blaylock claimed. - Aug 4 ********************* http://www.independent.co.uk/enjoyment/Food_and_Drink/News/ buckling080100.shtml Buckling, bloaters and the game of the season A New Year's resolution to eat healthily needn't mean a dull diet. The shops are full of exotic imports, plus the best local produce. By Sybil Kapoor 8 January 2000 Are you feeling as fat as a pig? Can't look at another chocolate? Fed up with cooking, eating and food in general? Don't despair – you are suffering from post-millennium excess. At least it makes abstinence seem alluring. Time, I feel, to peel a refreshingly healthy clementine and contemplate life. In the last few years the food world has changed enormously. Shoppers now have to contend with genetically modified ingredients and a cocktail of additives such as MSG and aspartame. We have to consider whether we want organic, artisan, farm-friendly or mass-produced food. And if that were not enough, we have the choice of buying from the Internet, box schemes, supermarkets, village stores, farmer's markets, street markets or farm shops. Every decision we make has a repercussion. The simple act of reading a label and selecting on the basis of origin can make or break an industry. English apple growers, for example, suffered last autumn from supermarket shoppers choosing to buy the cheaper European imports. Contrary to popular belief, we can, and do, influence what we are sold. Dorcas Jamieson, the head of consumer affairs at Sainsbury's, explains: "We constantly monitor customer demand and change our products accordingly." Within days of the first few phone calls about the safety of GM foods to their customer service department, Sainsbury's began to investigate the problem. By the time they were receiving 20,000 phone calls a week, they had already begun to remove all GM ingredients from their own labels. They are now working to eradicate them from the products of their suppliers. In the same way, the demand for organic produce has led them to increase their organic food from 100 to 500 items in one year. I, for one, have resolved to shop more responsibly this year as it seems to me that we have reached a crossroads in food production. It is time to signal how we want our food to be produced. If, for example, you don't want MSG in your food, you will have to read labels and boycott everything from Knorr's stock cubes to Jacob's Cheeselets. In the same way, if you want to support the rural economy you will have to buy home- grown produce before imports, and use farmer's markets or their shops. The same principles apply to organic produce. Foods containing GM ingredients are more problematic, but any expression of disquiet to shop, producer or MP will help. Such resolutions do not mean a dull diet. Quite the reverse. You can buy the best home-grown ingredients during their season, before supplementing them with exotic imports that would never grow in our chilly climate. Thus in January, you can enjoy the delicate stems of forced Yorkshire rhubarb, English apples and pears, sweet from storage, as well as juicy lychees, pomegranates and citrus fruit. For centuries, January has marked the arrival of Spanish lemons and Seville oranges. The latter are due to arrive today and will be around for the next two to three weeks, so marmalade makers had better pull out their preserving pans. Those not quite ready to start bottling could try freezing their Seville oranges whole – they will make good marmalade later. Those still with an appetite should buy some extra Seville oranges as they make a fantastic ceviche, as well as superb savoury butter sauces, creamy puddings, cakes and curds. Blood oranges and clementines are also in season now. The former makes a most reviving buck's fizz. Home`grown vegetables are still easy to buy in January, provided snow doesn't hamper supplies. Jerusalem artichokes should be at their peak and make deliciously sophisticated salads, as well as excellent soups, gratins and crisps. Keen gardeners and cooks might like to know that The Henry Doubleday Research Association is holding a National Potato Day at Ryton Organic Gardens, Coventry on Sunday 6 February, where you can taste and buy tubers from over 120 rare varieties. (For further information telephone 0247 630 8211.) However, if you tire of the many roots and greens available, you could always turn to salads and sprouts. The hardier bitter lettuces like raddichio, trevisse and Belgium endive all make gorgeous winter salads, although some can only be found in recherché greengrocers. Why can't one buy a whole escarole (batavia), curly endive (frisée) or feathery magenta-coloured trevisse (red chicory) from a supermarket? Incidentally, if you happen to dine on salad in a chic restaurant, look out for utterly scrumptious pea shoots and onion sprouts tossed into your leaves. Frances Smith, the grower for Appledore Salads in Kent, says that with a little care they could be grown at home. Sugar snap seeds yield the sweetest shoots – which are snipped before the first tendril unfurls. Onion or leek seeds are harder to grow, but they do have an exquisitely light allium flavour whether eaten fresh or stir- fried. Farmed mushrooms are another good winter choice. You can now buy cave- grown Blewitt mushrooms, along with shiitake, horse or brown mushrooms. As to the juicy oyster mushrooms, don't expect spectacular cooked colours from the yellow or pink versions, they always turn beige once cooked. All of these mushrooms work well together, particularly in warm salads and pasta. It is worth remembering that the game season ends on 31 January, so if you want to savour the last partridge, pheasant, wild duck, snipe or woodcock of the year, now is the time. They might be a bit chewy, so you will have to stew, pot or turn them into paté to appreciate their fine flavour. Fanned venison is available throughout the year and makes an excellent, tender winter dish. Those in need of lighter food should consider fish, in particular smoked fish. You can now mail-order from H Forman & Son (0181-985 4321) traditional British delicacies like smoked sprats, buckling and bloaters. The tiny sprats may be fiddly to eat, but they have a lovely flavour, fresh or smoked. Unfortunately, fishmongers can never guarantee their availability as they have become increasingly hard to sell in recent years. Buckling and bloaters are both ungutted herring, but buckling are hot smoked and can be eaten cold, while bloaters are cold smoked and should be lightly grilled with lashings of butter. Whoops, there goes the diet. Sybil Kapoor's latest book is 'Simply British' (Penguin, £7.99) ****************** http://www.guardianunlimited.co.uk/Archive/Article/0,4273,3889254,00 .html Cancer charity funds research into sweetener Links, reports and background on the GM food debate Linus Gregoriadis Wednesday August 4, 1999 British scientists have won a grant to study a possible link between an artificial sweetener used widely in diet drinks and brain cancer. A research team at King's college in London is to examine whether aspartame, marketed as NutraSweet, could cause brain tumours in people with a certain genetic make-up. NutraSweet, a brand owned by the food giant Monsanto, said yesterday that it welcomed the study but added that there was already "overwhelming scientific evidence" to prove the sweetener was safe. Peter Nunn, a neurochemist, and Geoff Pilkington, a cell biologist and neuropathologist, will begin a three-year study in October to examine whether brain cells in a culture are affected by the compound. Aspartame, which is 200 times sweeter than sugar, is made up of two naturally occurring amino acids - aspartic acid and phenylalanine - and methanol. The study will focus on whether methanol can affect DNA in some people. It is not suggested that aspartame could be a health risk to the general population. Dr Nunn said yesterday: "It is a serious study into whether people with certain genes are more susceptible to these compounds than others. We are going to be using brain cells which have got some specific mutations in them. These mutations may make these cells more sensitive to compounds like aspartame than other non-mutant cells would be." Aspartame was invented in 1965 but has been widely used in Britain only in the last few years. It was hailed as a breakthrough in the diet food and drink industry because, unlike saccharin, most adults like the taste. In 1996 a study by the American Association of Neuropathologists alleged a link between the widespread use of aspartame and a 10% increase in the incidence of brain tumours in the early 1980s in the US. The study was based on experiments with rats in 1978. NutraSweet said the scientists had "manipulated" their results and pointed to other studies which showed its product was safe. The British government's committee on carcinogenicity agreed there were flaws with the American study and rejected the allegation. NutraSweet said it had no doubt that the new research would show there was no link to brain tumours. "The study will provide a further opportunity to put these groundless rumours to rest," the company said. Dr Nunn and his team have received a £147,000 grant from the Samantha Dickson research trust. The trust, which was set up by Angela and Neil Dickson after their daughter Samantha died from cancer, received the money from the national lottery charities board. Dr Nunn said the value of the study had been scrutinised by independent scientists. He added: "Primary brain tumours are of considerable interest to everybody because the cause of them is not known. This study does not set out to rubbish aspartame." NutraSweet said in its statement: "There is already an overwhelming amount of scientific evidence which confirms the safety of aspartame, but scaremongers have continued to claim that aspartame is linked to brain tumours." It added: "It is physiologically impossible for aspartame to cause brain tumours because it never enters the bloodstream and thus cannot travel to essential organs, including the brain." ****************** http://www.guardianunlimited.co.uk/Archive/Article/0,4273,3809512,00 .html Over-the-counter pills 'can contain banned levels of arsenic' By Sarah Boseley Tuesday January 19, 1999 Vitamin pills and cold remedies available over the counter may contain undeclared sweeteners and banned levels of additives, like arsenic and lead, a report revealed yesterday. The Food Commission's survey found unexpected items including synthetic colourings and animal and insect-derived ingredients. The companies are within the law, said the commission, but it calls for more stringent rules on labelling so that the consumer knows the contents. "We found some companies hide the information in small print while others do not declare their full ingredient list at all, and some make you open the packet to find out what you've been sold," said Tim Lobstein, co-director of the Food Commission. Researchers found vitamin pills containing colouring agents that have been banned from virtually all foods, such as Redoxon slow-release vitamin C, which contains erythrosine. Lemsip and Resolve were sweetened first with sugar and then again with artificial sweeteners. Beechams All-In-One contained three sweetening agents, two artificial colourings and alcohol. Tums was found to be principally made of chalk, with added sugar, starch, flavouring and four artificial colours. Dr Lobstein said it cost £30 per kilo. Headache powder Resolve and stomach settling remedy Rap-Eze are coloured with coal tar dyes. Lemsip, from Reckitt and Colman, like many vitamin pills including Redoxon, Sanatogen, Bassett's, Super Ted and Superdrug, contains aspartame as a sweetener. Rennie has saccharin. Bassett's Soft and Chewy Vitamins and Sanatogen multivitamins and iron contain cochineal, a red dye made from cactus beetle carcasses. The research published in the Food Magazine, also cites government-run tests which found high levels of sodium in Boots effervescent vitamin C, and high levels of lead and arsenic in several supplements. ****************** http://www.telegraph.co.uk:80/et?ac=002496304413067&rtmo=Vw4kjkjx&atmo =tttttttd&pg=/et/99/8/10/thprob10.html Oh, I do miss my old, sweet life Dr Sarah Brewer investigates natural alternatives to sugar? Plus, the truth about mixing alcohol and antibiotics DEAR DOCTOR - I was recently advised to cut back on my use of sugar, as diabetes runs in my family. I've had sugar in tea and coffee all my life and am finding it difficult to give up. Sweeteners taste artificial and I understand they might be linked with an increased risk of cancer. It was announced only yesterday that scientists in Britain are to investigate the link between the sweetener aspartame - marketed under the name NutraSweet - and an increased risk of primary brain tumours. While the manufacturer said there was "overwhelming scientific evidence" that the product was safe, it is a good idea to limit your intake of food additives, such as preservatives, artificial colouring agents and artificial sweeteners. Luckily, there is a naturally sweet, calorie-free alternative. Stevia, a plant found in the Brazilian rainforests, contains substances that are at least 100 times sweeter than cane sugar. When extracted, these can be concentrated into a liquid that is 400 times sweeter than table sugar. Stevia is available as dried leaves, powdered extract or liquid extract and is a virtually calorie-free alternative to sugar. Add one or two dried leaves to your teapot during brewing, use powdered leaves when cooking, or add a drop of liquid extract to sweeten a cup of tea or coffee. Stevia has a natural antibiotic action that protects against gum disease and tooth decay, and is also safe for use by diabetics. Available by mail order from Rio Trading: 01273 570987. 2 February 1999: Forget fat - sugar is the new enemy DEAR DOCTOR - My GP tells me I have a condition known as bacterial vaginosis. What is this? Is it sexually transmissible? Bacterial vaginosis (BV) is an imbalance in the bacteria found in the vagina, in which levels of healthy bacteria such as Lactobacillus acidophilus are reduced (or absent), while those bacteria usually found in small numbers flourish. Increased numbers of anaerobic bacteria are present which, because they do not use oxygen for metabolism, produce chemicals that can cause irritation, unpleasant odours and increased discharge. Some women do not get noticeable symptoms, although their partners may develop irritation after sex if they have not used condoms. As many as one in four women will experience bacterial vaginosis. The cause is unknown, and BV is not classed as a sexually transmissible disease, although it is more common in sexually active women. BV doubles the risk of miscarriage during the first three months of pregnancy and is also associated with an increased risk of pre-term labour. It is treated with antibiotics, such as metronidazole. Unfortunately, it often seems to recur. Taking acidophilus capsules and smearing on live bio yogurt might help replenish the numbers of healthy bacteria. DEAR DOCTOR - I've heard conflicting reports about whether you can drink alcohol when taking antibiotics. I'm currently taking antibiotics for acne. Can I indulge? Always follow the instructions supplied with your medication. Most antibiotics do not interact with alcohol, and you can drink in moderation when taking them. Only one oral antibiotic (metronidazole) interacts with alcohol to produce elevated levels of acetaldehyde, a poison that produces flushing, headache, palpitations, nausea and vomiting. You should therefore avoid alcohol when taking metronidazole. The traditional warning about not drinking alcohol when taking penicillin seems to stem from its use, earlier this century, in treating venereal diseases. Physicians banned alcohol for fear their patients would get drunk, lose their inhibitions and spread their syphilis or gonorrhoea before they were fully treated. 21 February 1998: Pro and antibiotics DEAR DOCTOR - My husband was recently taken ill during a holiday in France and was diagnosed with angina pectoris. I feel that being overweight does not help him. What is the healthiest way for him to lose it? Losing excess fat is important, as those who are overweight are one-and- a-half times more likely to have a heart attack than those who maintain a healthy weight. If you are obese, the risk is doubled - especially if you store excess fat around your middle. Studies show that the overweight people who are most successful at losing weight - and maintaining that loss - are those who follow a low- fat diet and increase their level of activity. People who exercise for 20-30 minutes, at least five times a week, are half as likely to have a heart attack as those who are physically inactive. Your husband should aim to lose no more than 1-2lb a week and should ask his GP how much exercise is suitable for his heart condition. Activities such as DIY, gardening and dancing can be just as effective for heart health as swimming or cycling. Introduce your husband to low-fat meals, use salt sparingly in cooking and increase his intake of fruit, vegetables and oily fish. Use olive or rapeseed oil in cooking. Supplements such as folic acid, antioxidants (especially high-dose vitamin E), fish oils and garlic powder tablets all help to maintain a healthy heart and circulation. Health food shops offer a good selection. DEAR DOCTOR - I have a problem called Rosacea, which affects my nose and cheeks. I understand there is a treatment that involves lasers. Can you tell me anything about it? Rosacea is an inflammatory skin condition in which the face flushes easily and small pimples appear along with fine, dilated capillaries. Creams and glycolic acid facial washes are the mainstay of treatment. The new KTP laser therapy can control the condition by destroying the dilated capillaries with a series of brief laser pulses. Each pulse lasts only a few thousandths of a second, so heat does not build up in the skin. The laser light is selectively absorbed by blood within the dilated vessels and normal skin is unaffected. Up to three treatments, of 30 minutes each, are needed, six to eight weeks apart. For a fact sheet, call Lasercare on 0800 0287222. Information on Rosacea and its treatment is available from the Acne Support Group; send an sae to PO Box 230, Hayes, Middlesex UB4 0UT, for details of membership. 30 May 1998: Doctor's Diary: Help for rosacea sufferer Letters should be sent to Dr Sarah Brewer, Features Department, The Daily Telegraph, Canada Square, Canary Wharf, London E14 5DT; fax 0171- 513 2508. Letters cannot be answered personally. Before following any advice, please consult your GP. No responsibility can be taken for advice given in this column. Questions can also be sent by e-mail: drsarah@bizonline.co.uk ****************** http://www.telegraph.co.uk:80/et?ac=002496304413067&rtmo=Vw4kjkjx&atmo =tttttttd&pg=/et/97/5/17/tlcall17.html What service can you expect from medical, fitness and diet establishments? We telephone them anonymously to find out The Coca-Cola Information Line This week's call is to the Coca-Cola Freephone Consumer Information Line, whose number is printed just above the bar code on cans of Diet Coke. A report published in the US Journal of Neuropathology last year suggested that the artificial sweetener aspartame, marketed as Nutrasweet and used in Coca-Cola's diet range, can cause brain cancer. Both Nutrasweet and Coca-Cola have disputed these claims. The call is picked up by an automatic switchboard, which then transfers it to the information line. A middle-aged woman with an Estuary English twang answers. Information, how can we help you? [Great emphasis is placed on both the "we" and the "you"] Well, I'm worried about Nutrasweet. I've heard it's bad for you and I wondered if you could tell me a bit about it. Oh [not pleased]. We buy Nutrasweet from another company - I can send you information on artificial sweeteners generally, but I can't talk about Nutrasweet specifically. The Nutrasweet Company is based in London though - would you like their number? OK. It's 0171 636 9068, and they'll be able to answer all your questions. But I've heard it can give you cancer. . . I can't comment on someone else's product. But you put it in your drinks? Yes, but we don't just use Nutrasweet, we use other sweeteners as well. That's why I can only send information about sweeteners in general. Coca-Cola is our brand logo and I can answer in-depth questions about that, but Nutrasweet is not our own brand. I don't know the individual ingredients that go into it. But do speak to Nutrasweet, OK? [Obviously keen to hang up] And will Diet Coke help me lose weight? Only as part of a calorie-controlled diet. Diet Coke has 1.5 calories whereas normal Coke has 142, because it's full of sugar. [As if to a rather stupid child] If you go to your supermarket, lots of the products there that have "diet" written on them are very low in calories. But Diet Coke isn't a slimming product at all. I see. What about my teeth? Is it bad for my teeth? [Voice moves up a key] Coke has been around for 111 years, the ingredients have not changed in 111 years and there's no way it would have been going that long if the ingredients were bad for you. People talk about sweet drinks but drinks don't stay in your mouth long enough to be bad for your teeth. OK? [Voice becomes impatient, sounding keen to hang up] So is there a limit to the amount I should drink? Well, we're not medical people, I hasten to say. But medical people say you can drink seven litres a day. That's three cans to a litre. OK then? [Barely waits for caller to say OK before hanging up] Verdict The artificial sweetness of the information line operator ran out very quickly. ****************** http://www.telegraph.co.uk:80/et?ac=002496304413067&rtmo=Vw4kjkjx&atmo =tttttttd&pg=/et/99/8/4/nsweet04.html Scientists study sweetener after cancer fears By Celia Hall, Medical Editor A THREE-YEAR study is being launched by British scientists to look at possible links between the sweetener aspartame and brain cancer. It will look specifically at whether the sweetener, widely used in diet drinks and other products, can trigger primary brain cancer in cells that are known to be prone to the disease. Aspartame, well known by its tradename NutraSweet, is 200 times sweeter than sugar. Four years ago the American Association of Neuropathologists, concerned about a rise in brain tumours, suggested a link with aspartame after studies in rats. The new work, supported by a £147,000 grant from a small child cancer charity, will also receive a national lottery grant. It is being led by Dr Peter Nunn, a biochemist and Dr Geoffrey Pilkington, a cell biologist at King's College, London. They had already conducted a pilot study The sweetener is marketed in Europe by NutraSweet AG. A spokesman said it welcomed any study that proved the safety of the product. She said: "There is already an overwhelming amount of scientific evidence which confirms the safety of aspartame. Allegations about aspartame and brain tumours were studied and dismissed by scientists and regulatory agencies around the world as recently as in 1997." Hans Heezen, vice president of NutraSweet AG, said: "Although we will be glad to have yet further evidence to add to the wealth of data that already demonstrates aspartame's safety, it seems that money which has been allocated, could more usefully be directed to other research products." Dr Nunn said yesterday that the study was interested in one constituent of aspartame, methanol which could be incorporated into tissue and could cause changes in DNA. He said: "We are trying to focus down to see if aspartame, and other agents can generate changes in cells already known to be susceptible." The research grant is from the Samantha Dickson Research Trust set up by Angela and Neil Dickson after their daughter died from a brain tumour six days before her 17th birthday in 1996. Mrs Dickson, of Hook, Hampshire, said: "We are funding six projects to try to find a cure for brain tumours. "This particular project has nothing to do with the way Samantha died. We asked for applications for research projects and this was one of them. We don't know if there is a link [between aspartame and brain cancer], but this project will help us to find out about it." ****************** http://www.lineone.net/express/00/01/09/news/n0120war-d.html Bitter war of words over the safety of $1 billion sweetener By Lucy Johnston ****************** http://www.lineone.net/express/00/01/09/news/n0100splash-d.html Prove that diet drinks are safe INVESTIGATION By Lucy Johnston ****************** http://www.lineone.net/express/00/01/16/news/n1320diet-d.html My two years of hell on low calorie drinks Lyn Hunter ****************** http://www.sunday- times.co.uk/news/pages/sti/2000/02/27/stinwenws03032.html?999 Top sweetener condemned by secret report Jonathan Leake, Science Editor ****************** feedback@pa.press.net http://www.pa.press.net/info/email/main.html -------- assorted news sites aol.com http://www.aol.com/ aol.co.uk http://www.aol.co.uk/ Breathe.net http://www.breathe.net/ Bun.com http://www.bun.com Carlsberg http://www.carlsberg.co.uk/ Cellnet Genie http://www.genie.co.uk/ Compuserve http://www.compuserve.co.uk/ Excite http://www.excite.co.uk/ Express Sport Live http://www.sportlive.net/ FA Carling Premiership http://www.fa-carling.com/ Freeserve http://www.freeserve.net/ Guardian Unlimited http://www.guardianunlimited.co.uk/ In2home.net http://www.in2home.co.uk/ Lineone http://www.lineone.net/ Lord's http://www.lords.org/ Madasafish.com http://www.madasafish.com/ Megastar http://www.megastar.co.uk/ Mirago http://www.mirago.co.uk/ Mistral Internet http://www.mistral.co.uk/ MSN http://www.msn.co.uk/ Nationwide Building Society http://www.nationwide.co.uk/ Netline UK http://www.netlineuk.net/ Netscape Online http://www.netscapeonline.co.uk/ Newitts http://www.newitts.com/ Orange http://www.orange.co.uk/ Plusnet Technologies http://www.plusnet.co.uk/ Pointcast http://www.pointcast.com/ Powernet http://www.powernet.co.uk/ Sage Software http://www.uk.sage.com/ Scotland Online http://www.scotland.net/ Scottish Widows http://www.scottishwidows.co.uk/ Screaming.net http://www.screaming.net/ Scrum.com http://www.scrum.com/ Teletext http://www.teletext.co.uk/ Tesco http://www.tesco.net/ Tetley http://www.smoothlydoesit.co.uk/ This Is London http://www.thisislondon.co.uk/ Totalise http://www.totalise.co.uk/ ugenie http://www.u.genie.co.uk/ UK Max http://www.ukmax.co.uk/ Vodafone http://www.vodafone.co.uk/ Videoway http://www.videoway.com/ Yahoo UK & Ireland http://www.yahoo.co.uk/ Yell http://www.yell.co.uk/ Wcities.net http://www.wcities.com/