Artificial sweeteners This category of nonnutritive, high-intensity sugar substitutes includes ASPARTAME, ACESULFAME-K and SACCHARIN. Two sweeteners undergoing FDA approval at this writing are ALITAME and SUCRALOSE. Cyclamate lost its FDA approval in 1970. Numerous new sweeteners are in various stages of development or review. Most of these are from two groups: the fructo-oligosaccharides (FOS) and the L-sugars. aspartame aspartame [ah-SPAHR-taym; AS-pahr-taym] An ARTIFICIAL SWEETENER that's 180-200 times sweeter than sugar. It's synthesized from two AMINO ACIDS (aspartic acid and phenylalanine), the building blocks of protein, and contains about 4 calories per gram. Regular aspartame breaks down and loses its sweetness when heated but is excellent for sweetening cold dishes. A new encapsulated (and therefore heat-stable) form of this sweetener has been developed especially for baking. At this writing, however, it's not available to consumers. Acesulfame-K Acesulfame-K [a-seh-SUHL-faym-K] Formulated by the Germans in the late 1960s, this noncaloric ARTIFICIAL SWEETENER (also called Ace-K ) was approved in the United States by the Federal Drug Administration in 1988. It's 200 times sweeter than sugar and, unlike ASPARTAME, retains its sweetness when heated, making it suitable for cooking and baking. When used in large amounts, however, Ace-K has a bitter aftertaste, much like that of SACCHARIN. This sweetener is composed of carbon, nitrogen, oxygen, hydrogen, sulphur and potassium atoms. It's widely used in a broad range of commercial products including baked goods, candies and imitation dairy products. Alitame Alitame [AL-ih-taym] Although not sanctioned for use in the United States at this writing, Alitame is expected to soon become FDA approved. This supernova of ARTIFICIAL SWEETENERS is 2,000 times as sweet as sugar. It's a compound of two amino acids ­ alanine and aspartic acid. saccharin saccharin [SAK-uh-rihn] Containing only 1 calorie per teaspoon, this ARTIFICIAL SWEETENER is said to be 300 times sweeter than sugar. Saccharin was discovered by accident in the late 1800s by scientists at Johns Hopkins University. Though it's widely used to sweeten a multitude of commercial foods and beverages - as well as in the home - some find that it has a decidedly bitter aftertaste. This unpleasant effect is particularly noticeable when a food sweetened with saccharin is heated. Saccharin is available in both powdered and liquid forms in supermarkets. It has been the center of controversy during the last few decades because of its reported possible carcinogenic effects. Because the issue is still being researched, the FDA requires that saccharin products carry a warning label to that effect. Sucralose Sucralose An ARTIFICIAL SWEETENER that's about 600 times sweeter than sugar. Although not approved by the Federal Drug Administration at this writing, Sucralose is already being used in Australia and Canada under the brand name Splendar . This crystalline, free-flowing sweetener is both water soluble and stable, making it appropriate for a broad range of foods and beverages.