METHYL ALCOHOL
(from: NTP CHEMICAL REPOSITORY)
NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
-IDENTIFIERS
===========
*CATALOG ID NUMBER: 001879
*CAS NUMBER: 67-56-1
*BASE CHEMICAL NAME: METHYLALCOHOL
*PRIMARY NAME: METHYL ALCOHOL
*CHEMICAL FORMULA: CH4O
*STRUCTURAL FORMULA: CH3OH
*WLN: Q1
*SYNONYMS:
CARBINOL
COLONIAL SPIRIT
COLUMBIAN SPIRIT
METHANOL
METHYLOL
METHYL HYDROXIDE
MONOHYDROXYMETHANE
PYROXYLIC SPIRIT
WOOD ALCOHOL
WOOD NAPHTHA
WOOD SPIRIT
NA 1230 (DOT)
UN 1230 (DOT)
RCRA WASTE NUMBER U154
-PHYSICAL CHEMICAL DATA
======================
*PHYSICAL DESCRIPTION: LITERATURE: Colorless liquid
REPOSITORY: Clear colorless liquid
*MOLECULAR WEIGHT: 32.04
*SPECIFIC GRAVITY: 0.7913 @ 20/4 C
*DENSITY: 0.796 g/mL @ 15 C
*MP (DEG C): -98 C
*BP (DEG C): 64.6 C
*SOLUBILITIES:
WATER : >=100 mg/mL @ 21 C (RAD)
DMSO : >=100 mg/mL @ 21 C (RAD)
95% ETHANOL : >=100 mg/mL @ 21 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 21 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Miscible
Ketones: Miscible
Most organic solvents: Soluble
ETHER : Miscible
BENZENE: Miscible
*VOLATILITY:
Vapor pressure: 100 mm Hg @ 21.2 C; 237.87 mm Hg @ 38 C (RAD)
Vapor density : 1.11
*FLAMMABILITY(FLASH POINT):
The flash point of this chemical is 11 C (52 F). It is flammable. Fires
involving this material can be controlled with a dry chemical, carbon dioxide
or Halon extinguisher. The autoignition temperature of this compound is
463.89 C (867 F).
*UEL: 36.5% LEL: 6.0%
*REACTIVITY:
This compound may react violently with acids, acid chlorides, acid anhydrides,
oxidizing agents, reducing agents and alkali metals.
*STABILITY:
The neat chemical is stable under normal laboratory conditions. Solutions of
this chemical in water, DMSO, 95% ethanol and acetone should be stable for
24 hours under normal lab conditions (RAD).
*OTHER PHYSICAL DATA:
Refractive index: 1.3292 @ 20
ulc= 70
Odor threshold: 4.3 ppm
Highly polar
Slight alcoholic odor
-TOXICITY
========
*NIOSH REGISTRY NUMBER: PC1400000
*TOXICITY:
typ. dose mode specie amount units other
LDLo orl hmn 340 mg/kg
TCLo ihl hmn 86000 mg/m3
LDLo unr man 868 mg/kg
LD50 orl rat 5628 mg/kg
LC50 ihl rat 64000 ppm/4H
LD50 ipr rat 9540 mg/kg
LD50 orl mus 870 mg/kg
LCLo ihl mus 50 gm/m3/2H
LDLo ipr mus 120 mg/kg
LD50 scu mus 9800 mg/kg
LD50 ivn mus 5673 mg/kg
LDLo orl dog 7500 mg/kg
LDLo orl mky 7000 mg/kg
LCLo ihl mky 1000 ppm
LDLo skn mky 500 mg/kg
LCLo ihl cat 44000 mg/m3/6H
LDLo ivn cat 118 mg/kg
LDLo orl rbt 7500 mg/kg
LD50 skn rbt 20 gm/kg
LDLo orl man 13 gm/kg
*AQTX/TLM96: >1000 ppm
*SAX TOXICITY EVALUATION:
THR = A skin, eye irritant. A human inhalation IRRITANT. A human eye
irritant. HIGH human oral; HIGH intraperitoneal, intravenous; MODERATE
inhalation, oral, skin; LOW skin, oral, inhalation, intraperitoneal,
subcutaneous. Methyl alcohol possesses distinct narcotic properties.
Coma from massive exposures may last as long as 2-4 days.
*CARCINOGENICITY: Not available
*MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ------------ -----------------
mmo-smc 12 pph | cyt-smc 500 umol/tube
cyt-grh-par 3000 ppm | dni-hmn:lym 300 mmol/L
dnd-rat-orl 10 umol/kg | cyt-mus-orl 1 gm/kg
cyt-mus-ipr 75 mg/kg | mma-mus:lym 7900 mg/L
*TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-rat 7500 mg/kg (17-19D preg)
TCLo: ihl-rat 20000 ppm/7H (1-22D preg)
TDLo: ipr-mus 5 gm/kg (5D male)
*STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 200 ppm [610]
Final Limit: PEL-TWA 200 ppm (skin); STEL 250 ppm [610]
ACGIH: TLV-TWA 200 ppm (skin); STEL 250 ppm [610]
NIOSH Criteria Document: Recommended Exposure Limit to this compound-air:
PEL-TWA 200 ppm; Ceiling Limit 800 ppm/15M [610]
NFPA Hazard Rating: Health (H): 1
Flammability (F): 3
Reactivity (R): 0
H1: Materials only slightly hazardous to health (see NFPA for details).
F3: Materials which can be ignited under almost all normal temperature
conditions (see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
*OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-hmn 5 ppm
skn-rbt 500 mg/24H MOD
eye-rbt 40 mg MOD
Review: Toxicology Review-5
Standards and Regulations: DOT-Hazard: Flammable liquid; Label: Flammable
liquid
DOT-IMO: Flammable liquid; Label: Flammable liquid,
Poison
Status: "NIOSH Manual of Analytical Methods, 3rd Ed."
Reported in EPA TSCA Inventory, 1983
EPA Genetic Toxicology Program, January 1984
EPA TSCA Section 8(e) Status Report 8EHQ-0378-0108
Meets criteria for proposed OSHA Medical Records Rule
-OTHER DATA (Regulatory)
=======================
*PROPER SHIPPING NAME (IATA): Methanol
*UN/ID NUMBER: UN1230
*HAZARD CLASS: 3 SUBSIDIARY RISK: 6.1 PACKING GROUP: II
*LABELS REQUIRED: Flammable liquid and Poison
*PACKAGING: PASSENGER: PKG. INSTR.: 305, Y305 MAXIMUM QUANTITY: 1 L, 1 L
CARGO : PKG. INSTR.: 307 MAXIMUM QUANTITY: 60 L
*SPECIAL PROVISIONS: None
*USES:
Industrial solvent; starting material for organic synthesis of formaldehydes,
methyl esters of organic and inorganic acids, methacrylates, methylamines,
methyl anhydrides, ethylene glycol and pesticides; antifreeze for automotive
radiators and air brakes; ingredient of gasoline and diesel oil antifreezes;
octane booster in gasoline; as fuel for picnic stoves and soldering torches;
extractant for animal and vegetable oils; denaturing ethanol; softening agent
for pyroxylin plastics; solvent adjuvant for polymers; solvent in the manu-
facturing of cholesterol, streptomycin, vitamins, hormones and other pharma-
ceuticals; food additive permitted in foods for human consumption (???);
ingredient in paint, varnish removers, cleaning and dewaxing preparations, spirit
duplicating fluids and embalming fluids; used in the manufacture of photo-
graphic film, celluloid, textile soap, wood stains, coated fabrics, shatter-
proof glass, paper coating, waterproofing formulations, artifical leather,
synthetic indigo and other dyes.
[Note: (???) I wonder when that was added, and by whom! More to the point... WHY?]
*COMMENTS:
RLT 860527, RAS 860527
-HANDLING PROCEDURES
===================
*ACUTE/CHRONIC HAZARDS:
This compound may cause severe skin and eye irritation. It can be absorbed
through the skin. It may cause narcosis.
*MINIMUM PROTECTIVE CLOTHING: Not available
*RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemical:
Recommendations based on permeation test results are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): No information available
*RECOMMENDED RESPIRATOR:
When working with this chemical, wear a NIOSH-approved full face
positive pressure supplied-air respirator or a self-contained breathing
apparatus (SCBA). [651]
*STORAGE PRECAUTIONS:
You should store this chemical in an explosion-proof refrigerator
and keep it away from oxidizing materials. STORE AWAY FROM SOURCES
OF IGNITION.
*SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Seal the absorbent
paper, as well as any of your clothing which may be contaminated, in a vapor-
tight plastic bag for eventual disposal. Wash any surfaces you may have
contaminated with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
*DISPOSAL AND WASTE TREATMENT:
Not available
*OTHER: Not available
-EMERGENCY PROCEDURES
====================
*SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
*INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
*EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
*INGESTION:
DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being
aspirated into the victim's lungs during vomiting which increases the medical
problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
*SYMPTOMS:
Symptoms of exposure to this compound may include headache, fatigue, nausea,
dizziness, stupor, cramps, dermatitis, visual impairment or complete blindness
(may be permanent); acidosis, convulsions, mydriasis, circulatory collapse,
respiratory failure, death, irritation of mucous membranes, damage to the
central nervous system (especially the optic nerve), injury to the kidneys,
liver, heart and other organs; peripheral neuritis, gastrointestinal distur-
bances, photophobia and conjuctivitis, followed by definite eye lesions;
narcosis, unconsciousness, shallow breathing, cyanosis, coma, fall in blood
pressure, hyperemia of the optic disk with blurring of the margin; burning
sensation, coughing, wheezing, laryngitis, vomiting, delirium, pain in the
eyes, giddiness, vertigo, severe abdominal pain, back pain, dyspnea, motor
restlessness, cold clammy extremities and diarrhea.
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=======
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