Here is everything I could dig up on this fellow. Notice that he MUST work on a "shoestring" because his "department" consists of himself (and he is WEBmaster for his pages), a PA, an LPN, and a clerk. Not exactly "top drawer". Info from original WEB site ********************************************************** http://www.omrf.ouhsc.edu/ http://www.omrf.ouhsc.edu/OMRF/Research/17/ManionC.html "Carl V. Manion, M.D." Member and Head, Clinical Pharmacology Research Program B.A., Hastings College, 1961 M.D., University of Colorado, 1965 Intern, University of Kansas, 1966 Resident, Internal Medicine, University of Kansas, 1969-72 Fellow, Clinical Pharmacology, University of Kansas, 1972-74 Memberships American College of Physicians American Medical Association American Society for Internal Medicine American Society for Clinical Pharmacology and Therapeutics New York Academy of Science Other Activities Editorial board, Clinical Pharmacology and Therapeutics Research Interests Clinical trials establishing the safety and effectiveness of new medicines for treatment of hypertension, asthma, heart failure and arthritis. Joined OMRF Scientific Staff in 1994. ******************************************************** http://www.omrf.ouhsc.edu/OMRF/Research/17/home/WebDoc1.htm Current Research Projects ALLHAT....This study funded by NIH will ultimately involve 40,000 patients with high blood pressure. Four basic treatments for high blood pressure are being evaluated to understand which medicines, treatment foundations, are best, and why. LIFE........... This study funded by MERCK is comparing a currently available MERCK drug with another commonly used high blood pressure medicine in patients whose chronic blood pressure problems have already injured their heart. The goal is to understand if eiher medicine has long term advantages in preventing progession of heart injury from high blood pressure. REACH 2 .. This study funded by Roche Laboratories will evaluate a very new medicine that will be added to the usual treatment for Congestive Heart Failure. The new medicine will address lowering the levels of Endothelin a substance observed to be elevated in heart failure and probably adding to the problems that heart failure presents. Diabetic Kidney Disease Evaluation This study funded by Bristol Myers- Squib is a long term evaluation of the "protective effects" from two types of medication used for treating high blood pressure in diabetics. The study follows diabetic patients for several years to understand if the changes observed thought to be important to good kidney health and stable diabetes actually occur. Which Blood Pressure Medicine is Better This study funded by Bristol Myers Squibb is a limited in duration study to evaluate two currently available blood pressure medicines. Which is more easily tolerated. Clinical Pharmacology Initiatives Aspartame and Osteoarthritis Aspartame and Rheumatoid Arthritis Aspartame and Lupus Antiviral Effects of Methylene Blue Return to Table of Contents Last Updated February 12, 1998 by Carl V. Manion MD ********************************************************** http://www.omrf.ouhsc.edu/OMRF/Research/17/home/WebDoc5.htm Current Research Staff Carl V. Manion MD Doctor Manion is a general internist with special training in clinical pharmacology. He has practiced in Oklahoma City for more than 20 years. His current research interests include hypertension, heart failure, diabetes, and arthritis. Ernest Wilson PA Mr. Wilson is a physicians's assistant who has worked at OMRF for more than 10 years. He has been an instrumental part of the study of Cholesterol medications for heart disease done at OMRF. The recent publication in the New England Journal of Medicine of Cholesterol and Recurrent Events in October 1997 represents a most definitive contribution that has answered some fundamental questions on cholesterol reduction and heart disease. Marge Brassel LPN Ms. Brassel cares for the patients in the NIH and Life studies. She has been at OMRF for about 2 years. Her work has been instrumental in evaluations of the effects of aspartame. Fredonna Shelton (clerk) ********************************************************** http://www.omrf.ouhsc.edu/OMRF/Research/17/home/WebDoc3.htm Recent Clinical Pharmacology Communications Recent scientfic publications containing work done at OMRF include the following The New England Journal of Medicine Volume 335 Number 14, Oct 3 1997 The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels., F. M Sacks and Others Clinical Pharmacology and Therapeutics Volume 63 Number 1 Feb 1998 Abstract #3 Aspartame and Bleeding Time, E. Wilson, A. E. Edmundson, M. Brazel, and C.V. Manion. Abstract #119 Aspartame and Arthritis Pain Relief , C.V. Manion, A.E. Edmundson, M. Brasel, E. Wilson, Abstract #120 TNF‰Fì‰Vîf~ì Mice and Aspartame (APM), C.V. Manion, L. Stuart, M. Umber ********************************************************** Clinical Pharmacology Study Subjects The completion of studies in Clinical Pharmacology requires people who have particular kinds of medical problems. If you are interested call or write : Department of Clinical Pharmacology Oklahoma Medical Research Foundation 825 NE 13th St. Oklahoma City, OK 73112 405-271-7805