METHYL FORMATE (from: NTP CHEMICAL REPOSITORY) NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991) -IDENTIFIERS =========== *CATALOG ID NUMBER: 002010 *CAS NUMBER: 107-31-3 *BASE CHEMICAL NAME: METHYLFORMATE *PRIMARY NAME: METHYL FORMATE *CHEMICAL FORMULA: C2H4O2 *STRUCTURAL FORMULA: HCOOCH3 *WLN: VHO1 *SYNONYMS: FORMIC ACID, METHYL ESTER METHANOIC ACID METHYL ESTER METHYL METHANOATE UN 1243 R 611 -PHYSICAL CHEMICAL DATA ====================== *PHYSICAL DESCRIPTION: LITERATURE: Clear, colorless, mobile liquid REPOSITORY: Clear colorless liquid *MOLECULAR WEIGHT: 60.05 *SPECIFIC GRAVITY: 0.9742 @ 20/4 C [016,047] *DENSITY: 0.987 g/mL @ 15 C [421] *MP (DEG C): -99.8 C [038,043,055,062] *BP (DEG C): 31.5 C [016,029,031,043] *SOLUBILITIES: WATER : >=100 mg/mL @ 22 C (RAD) DMSO : >=100 mg/mL @ 22 C (RAD) 95% ETHANOL : >=100 mg/mL @ 22 C (RAD) METHANOL : Moderately soluble [043] ACETONE : >=100 mg/mL @ 22 C (RAD) TOLUENE : Not available OTHER SOLVENTS: Alcohol: Miscible [016,031,043,205] Ether: Soluble [016,047,062] *VOLATILITY: Vapor pressure: 400 mm Hg @ 16 C [038,043]; 476 mm Hg @ 20 C [058 ,102,421] Vapor density : 2.07 [043,055] *FLAMMABILITY(FLASH POINT): This chemical has a flash point of -32 C (-26 F) [058,205].It is flammable.Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.The autoignition temperature is 456 C (853 F) [036,062,102]. *UEL: 23% [058,102,421,451] LEL: 5% [058,102,421] *REACTIVITY: This chemical is incompatible with oxidizing agents such as hydrogen peroxide, nitric acid, perchloric acid or chromium trioxide [058].It is also incompatible with bases and acids [269].It reacts with (methanol + sodium methoxide) to form an explosive compound [043].It may decompose explosively [029,066].It may attack some forms of plastics, rubber and coatings [102]. *STABILITY: This chemical is sensitive to moisture and heat [269].Gas chromatography stability screenings indicate that solutions of this chemical in water are stable for less than 8 hours and that solutions in acetone are stable for at least 24 hours (RAD). *OTHER PHYSICAL DATA: Specific gravity: 0.987 @ 15/15 C [029,031]; 0.98149 @ 15/4 C [043] Specific gravity: 0.980 @ 20/20 C [058] Freezing point: -99 C [016 ,029,205] Vapor pressure: 1 mm Hg @ -74.2 C; 5 mm Hg @ -57.0 C; 10 mm Hg @ -48.6 C [038] Vapor pressure: 20 mm Hg @ -39.2 C; 40 mm Hg @ -28.7 C [038] Vapor pressure: 60 mm Hg @ -21.9 C; 100 mm Hg @ -12.9 C [038] Vapor pressure: 200 mm Hg @ +0.8 C; 760 mm Hg @ 32.0 C [038] Vapor pressure: 700 mm Hg @ 30 C [055] Flash point (open cup): -19 C (-2 F) [031,036,058,451] Strong, pleasant, fruity odor [058] Odor threshold: 2000 ppm [102] Saponified by water or alkaline solutions [062] 100% Volatile by volume [058] Evaporation rate (butyl acetate = 1): 100 [058] Refractive index: 1.3440 @ 20 C [031,047]; 1.3465 @ 15 C [205] -TOXICITY ======== *NIOSH REGISTRY NUMBER: LQ8925000 *TOXICITY: typ. dosemode specieamount units other LD50 orl rbt 1622mg/kg LCLo ihl gpg10000ppm LD50 orl rat1.6g/kg [058] *AQTX/TLM96: Not available *SAX TOXICITY EVALUATION: THR: Moderately toxic by ingestion.Industrial fatalities have occurred only with exposure to high concentrations. *CARCINOGENICITY: Not available *MUTATION DATA: Not available *TERATOGENICITY: Not available *STANDARDS, REGULATIONS & RECOMMENDATIONS: OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z Transitional Limit: PEL-TWA 100 ppm [015,327,545,610] Final Limit: PEL-TWA 100 ppm; STEL 150 ppm [015,545,610] ACGIH: TLV-TWA 100 ppm; STEL 150 ppm [015,415,421,610] NIOSH Criteria Document: None NFPA Hazard Rating: Health (H): 2 Flammability (F): 4 Reactivity (R): 0 H2: Materials hazardous to health, but areas may be entered freely with full-faced mask self-contained breathing apparatus which provides eye protection (see NFPA for details). F4: Very flammable gases or very volatile flammable liquids (see NFPA for details). R0: Materials which are normally stable even under fire exposure conditions and which are not reactive with water (see NFPA for details). *OTHER TOXICITY DATA: Review: Toxicology Review Standards and Regulations: DOT- Hazard: Flammable liquid; Label: Flammable liquid Status: EPA TSCA Chemical Inventory, 1986 IDLH value: 5000 ppm [058] -OTHER DATA (Regulatory) ======================= *PROPER SHIPPING NAME (IATA): Methyl formate *UN/ID NUMBER: UN1243 *HAZARD CLASS: 3 SUBSIDIARY RISK: NonePACKING GROUP: I *LABELS REQUIRED: Flammable liquid *PACKAGING: PASSENGER: PKG. INSTR.: 302 MAXIMUM QUANTITY: 1 L CARGO: PKG. INSTR.: 303 MAXIMUM QUANTITY: 30 L *SPECIAL PROVISIONS: None *USES: This compound is used as a fumigant and larvicide for tobacco, dried fruits and cereal.It is a fumigant for nuts and infected clothing.It is also a general industrial solvent for greases, fatty acids, cellulose acetate, collodion and celluloid.It is used in organic synthesis for the production of sulfa drugs, perfumes, dyes, military poison gases and embalming fluid. *COMMENTS: This compound should be shipped under dry ice. -HANDLING PROCEDURES =================== *ACUTE/CHRONIC HAZARDS: This compound is harmful by ingestion, inhalation and skin absorption [269].It has been reported to have been absorbed through human skin resulting in death [058].It may cause irritation [269].The vapor is heavier than air and can travel a considerable distance to a source of ignition and flash back [058].When heated to decomposition it emits acrid smoke, irritating fumes and toxic fumes of carbon monoxide, carbon dioxide and formic acid [043 ,058, 102,269]. *MINIMUM PROTECTIVE CLOTHING: Not available *RECOMMENDED GLOVE MATERIALS: GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical: This chemical has not been tested for permeation by Radian Corporation; however, the GlovES+ expert system was used to extrapolate permeation test information from compounds in the same chemical class.The GlovES+ system uses permeation data from literature sources; therefore, extra safety margins should be used with the estimated protection time(s).If this chemical makes direct contact with your glove, or if a tear, puncture or hole develops, replace them at once. The GlovES+ expert system is a tool that can help people better manage protection from chemicals, however this tool cannot replace sound judgment nor make technical decisions.Our GlovES+ expert system is designed to offer initial advice and assistance in glove selection while the final glove selection should be made by knowledgeable individuals based on the specific circumstances involved. Glove TypeModel NumberThickness Estimated Protection Time Butyl rubberNorth B- 1740.63 mm480 min PE/EVOH/PEBroste 4H Glove0.07 mm240 min PVA Edmont 25-5450.33 mm360 min Unknown North Silvershield 0.10 mm360 min *RECOMMENDED RESPIRATOR: When working with this chemical, wear a NIOSH-approved full face positive pressure supplied-air respirator or a self-contained breathing apparatus (SCBA). [651] *OTHER: Not available *STORAGE PRECAUTIONS: You should store this chemical in an explosion-proof refrigerator, and protect it from moisture.If possible, it would be prudent to store this compound under inert atmosphere.STORE AWAY FROM SOURCES OF IGNITION. *SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material.Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal.Wash any surfaces you may have contaminated with a soap and water solution.Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. *DISPOSAL AND WASTE TREATMENT: Not available -EMERGENCY PROCEDURES ==================== *SKIN CONTACT: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing.Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. *INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere.Whenever possible, Self- Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Respirator Recommendation. *EYE CONTACT: First check the victim for contact lenses and remove if present .Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. *INGESTION: DO NOT INDUCE VOMITING.Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center.IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body.DO NOT INDUCE VOMITING.IMMEDIATELY transport the victim to a hospital. *SYMPTOMS: Symptoms of exposure to this compound include irritation of the eyes and nose, retching, narcosis and death from pulmonary effects [031,043]. Inhalation of the vapor can cause optic neuritis and pulmonary irritation [043] .Central nervous system depression and irritation of the mucous mem-branes may occur [151,301].Irritation of the respiratory system may also occur [036,043] .Other symptoms include irritation of the throat, drowsiness and unconsciousness [102].Exposure may cause nausea, stupor, lung damage and skin irritation .Prolonged skin contact may lead to dryness and cracking [058]. -SOURCES ======= *SOURCES: [015] Lewis, R.J., Sr. and R.L. 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