CURRICULUM VITAE John W. Olney, M.D. BORN: October 23, 1931 - Marathon, Iowa MARITAL STATUS: Married CITIZENSHIP: U.S.A. EDUCATION:Iowa University, Iowa City, Iowa - B.A. 1956 Iowa University, Iowa City, Iowa - M.D. 1963 HONORS: Borden Undergraduate Research Award in Medicine 1963 NIMH Research Career Development Award 1968-1978 NIMH Research Scientist Award 1978-1998 Wakeman Award for Research in the Neurosciences 1992 Dana Foundation Award for Pioneering Achievement in Health 1994 Peter H. Raven Lifetime Award, Service & Accomplishments in Science 1996 The Society Biological Psychiatry, Lifetime Achievements Award 1996 Member, Institute of Medicine, National Academy of Sciences 1996 SOCIETY MEMBERSHIPS: Society for Biological Psychiatry New York Academy of Sciences Society for Neuroscience Psychiatric Research Society American Medical Association American Psychiatric Association American Psychopathological Association Association for Research in Nervous and Mental Diseases American Association of Neuropathologists International Brain Research Organization CERTIFICATION: Neurology and Psychiatry, 1970 MILITARY SERVICE: U.S. Army 1954-1956 INTERNSHIPS & RESIDENCIES: Internship (rotation) Kaiser Permanente Foundation San Francisco, California 1963-1964 Resident in Psychiatry, Washington University School of Medicine, St. Louis, Missouri 1964-1968 RESEARCH EXPERIENCE, ACADEMIC APPOINTMENTS, HOSPITAL APPOINTMENTS Biological Science Trainee, Washington University School of Medicine, St. Louis 1966-1968 Career Investigator Awardee, Washington University School of Medicine 1968- Assistant Psychiatrist, Renard Hospital, St. Louis 1968- Consulting Psychiatrist, Malcolm Bliss Mental Health Center, St. Louis 1968- Instructor in Psychiatry Washington University School of Medicine 1968-1969 Assistant Professor of Psychiatry Washington University School of Medicine 1969-1972 Associate Professor of Psychiatry Washington University School of Medicine 1972-1977 Associate Professor of Neuropathology Washington University School of Medicine 1976-1977 Professor of Psychiatry Washington University School of Medicine 1977- Professor of Neuropathology Washington University School of Medicine 1977- Member, NIMH Research Career Scientist Award Committee 1984-1988 Chairman, NIMH Research Career Scientist Award Committee 1986-1988 BIBLIOGRAPHY 1. Olney JW. An electron microscopic study of synapse formation, receptor outer segment development and other aspects of developing mouse retina. Invest Ophthal 7, 250-268, 1968. 2. Olney JW. Centripetal sequence of appearance of receptor-bipolar synaptic structures in developing mouse retina. Nature 218, 281-282, 1968. 3. Olney JW. Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate. Science 164, 719-721, 1969. 4. Olney JW. Glutamate-induced retinal degeneration in neonatal mice. Electron microscopy of the acutely evolving lesion. J Neuropathol Exp Neurol 28, 455-474, 1969. 5. Olney JW and Sharpe LG. Brain lesions in an infant rhesus monkey treated with monosodium glutamate. Science 166, 386-388, 1969. 6. Olney JW and Ho OL. Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine. Nature, 227, 609-610, 1970. 7. Perez VJ, Olney JW, Cicero TJ, Moore BW and Bahn BA. Wallerian degeneration in rabbit optic nerve: cellular localization in the central nervous system of S-100-14-3-2 proteins. J Neurochem 17, 511-519, 1970. 8. Olney JW. Glutamate-induced neuronal necrosis in the infant mouse hypothalamus: an electron microscopic study. J Neuropathol Exp Neurol 30, 75-90, 1971. 9. Olney JW, Ho OL and Rhee V. Cytotoxic effects of acidic and sulphur- containing amino acids on the infant mouse central nervous system. Exp Brain Res 14, 61-76, 1971. 10. Olney JW, Sharpe LG and Feigin RD. Glutamate-induced brain damage in infant primates. J Neuropathol Exp Neurol 3l, 464-488, 1972. 11. Perez VJ and Olney JW. Accumulation of glutamic acid in the arcuate nucleus of the hypothalamus of the infant mouse following subcutaneous administration of monosodium glutamate. J Neurochem 19, 1777-1781, 1972. 12. Olney JW, Ho OL, Rhee V and Schainker B. Cysteine-induced brain damage in infant and fetal rodents. Brain Res 45, 309-313, 1972. 13. Olney JW. A model for manipulating CNS cytotoxic effects between neuronal and non-neuronal compartments. J Neuropathol Exp Neurol 3l, l80, 1972. 14. Olney JW. Neurotoxic effects of acidic and sulphur-containing amino acids on developing central nervous system. J Neuropathol Exp Neurol 3l, 182, 1972. 15. Perez VJ, Olney JW and Robin SJ. Glutamate accumulation in infant mouse hypothalamus: influence of temperature. Brain Res 59, 181-189, 1973. 16. Olney JW, Ho OL and Rhee V. Brain damaging potential of protein hydrolysates. N Engl J Med 289, 391-395, 1973. 17. Olney JW. Status of monosodium glutamate revisited. Am J Clin Nutr 26, 683-689, 1973. 18. Olney JW, Ho OL, Rhee V and deGubareff T. Neurotoxic effects of glutamate. N Engl J Med 289, 1374-1375, 1973. 19. Cunningham L, Rich CL, Woodruff RA and Olney JW. Creatinine phosphokinase and psychiatric illness. Brit J Psychiat 124, 887-89l, 1974. 20. Olney JW. Occult mechanisms of brain dysfunction. In: Drugs and the Developing Brain. A Vernadakis and N Weiner (Eds), Plenum, New York, 1974. 21. Olney JW. Toxic effects of glutamate and related amino acids on the developing central nervous system. In: Heritable Disorders of Amino Acid Metabolism. WN Nyhan (Ed), John Wiley, New York, 1974, pp. 501-512. 22. Schainker B and Olney JW. Glutamate-type hypothalamic-pituitary syndrome in mice treated with aspartate or cysteate in infancy. J Neural Transm 35, 207-215, 1974. 23. Olney JW, Rhee V and Ho OL. Kainic acid: a powerful neurotoxic analogue of glutamate. Brain Res 77, 507-512, 1974. 24. Cicero TJ, Meyer ER, Wiest WB, Olney JW and Bell RD. Effects of chronic morphine administration on the reproductive system of the male rat. J Pharmacol Exp Ther 192, 542-548, 1975. 25. Sharpe LG, Olney JW, Ohlendorf C, Lyss A, Zimmerman M and Gale B. Brain damage and associated behavioral deficits following the administration of L-cysteine to infant rats. Pharmacol Biochem Behav 3, 291-298, 1975. 26. Olney JW, Misra CH and deGubareff T. Cysteine-S-sulfate: brain damaging metabolite in sulfite oxidase deficiency. J Neuropathol Exp Neurol 34, 167-176, 1975. 27. Misra CH and Olney JW. Cysteine oxidase in brain. Brain Res 97, 117-126, 1975. 28. Olney JW, Sharpe LG and deGubareff T. Excitotoxic amino acids. Neurosci Abst 1, 371, 1975. 29. Olney JW. Another view of Aspartame. In: Sweeteners; Issues and Uncertainties. Natl Acad Science Forum, US Govt Printing Office, 1975. 30. Olney JW. Brain damage and oral intake of certain amino acids. In: Transport phenomena in the Nervous System: Physiological and Pathological Aspects. G Levi, L Battistin and A Lajtha (Eds), Plenum, New York, 1976. 31. Olney JW, Schainker B and Rhee V. Chemical lesioning of the hypothalamus as a means of studying neuroendocrine function. In: Hormones, Behavior and Psychopathology. EJ Sachar (Ed), Raven, New York, 1976. 32. Olney JW, Cicero TJ, Meyer ER and deGubareff T. Acute glutamate-induced elevations in serum testosterone and luteinizing hormone. Neurosci Abst 2, 677, 1976. 33. Anandaraj MPJA, Jayaram HN, Olney JW and Cooney DA. Alanosine--a new anti-tumor antibiotic with properties of an analog and antagonist of L- aspartic and L-glutamic acids. Presented at Meeting of American Cancer Society, 1976. 34. Price MT, Olney JW and Cicero TJ. Proliferation of lamellar whorls in arcuate neurons of the hypothalamus of castrated and morphine-treated male rats. Cell Tissue Res 171, 277-284, 1976. 35. Olney JW, Cicero TJ, Meyer ER and deGubareff T. Acute glutamate-induced elevations in serum testosterone and luteinizing hormone. Brain Res 112, 420-424, 1976. 36. Misra CH and Olney JW. Synthesis of cysteine-35S-sulfate. J Labelled Compounds Radiopharma–ceuticals 13, 137-140, 1976. 37. Olney JW, Misra CH and Rhee V. Brain and retinal damage from the lathyrus excitotoxin, b-N-oxalyl-L-ab-diaminopropionic acid (ODAP). Nature 264, 659-661, 1976. . 38. Perez VJ, Olney JW, Frolichstein CF, Martin JF and Cannon WO. Regional uptake of neurotoxic and nontoxic amino acids in vivo by the infant mouse brain. Biochem Pharmacol 25, 1415-1419, 1976. 39. Olney JW, Rhee W, and deGubareff T. Neurotoxic effects of glutamate on mouse area postrema. Brain Res 120, 151-157, 1977. 40. Olney JW and deGubareff T. Excitotoxic amino acids and Huntington's chorea. J Neuropathol Exp Neurol 36, 619, 1977. 41. Olney JW, Fuller T and deGubareff T. Alanosine--an antileukemic agent with glutamate-like neurotoxic properties. J Neuropathol Exp Neurol 36, 619, 1977. 42. Misra CH, Mena EE, Rhee V and Olney JW. Intracellular distribution of cysteine oxidase in the rat central nervous system. Abst Fed Proc 36, 2522, 1977. 43. Price MT, Olney JW and Cicero TJ. Proliferation of lamellar whorls in arcuate neurons of the hypothalamus of male rats treated with estradiol benzoate or cyproterone acetate. Cell Tissue Res 182, 537-540, 1977. 44. deGubareff T and Olney JW. Intraventricular administration of potent excitotoxins may yield clues to location of glutareceptive neurons. Neurosci Abst 3, 515, 1977. 45. Olney JW, deGubareff T and Misra CH. D and L-isomers of homocysteic acid compared for neurotoxicity. Neurosci Abst 3, 518, 1977. 46. Price MT, Olney JW and Cicero TJ. Acute elevation of serum luteinizing hormone induced by low systemic doses of powerful neuroexcitatory analogs of glutamate. Neurosci Abst 3, 355, 1977. 47. Olney JW and deGubareff T. The fate of synaptic receptors in the kainate lesioned striatum. Brain Res 140, 340-343, 1978. 48. Olney JW and deGubareff T. Glutamate neurotoxicity and Huntington's chorea. Nature 271, 557-559, 1978. 49. Olney JW and Rhee V. Neurotoxic effects of glutamate on primate area postrema. J Neuropathol Exp Neurol 37, 669, 1978. 50. Olney JW. Neurotoxicity of excitatory amino acids. In: Kainic Acid as a Tool in Neurobiology. E McGeer, JW Olney, P McGeer (Eds), Raven, New York, 1978, pp 95-121. 51. Olney JW and deGubareff T. Extreme sensitivity of olfactory cortical neurons to kainic acid toxicity. In: Kainic Acid as a Tool in Neurobiology. E McGeer, JW Olney and P McGeer (Eds), Raven, New York, 1978 pp 201-217. 52. Olney JW and Price MT. Excitotoxic amino acids as neuroendocrine probes. In: Kainic Acid as a Tool in Neurobiology. E McGeer, JW Olney and P McGeer (Eds), Raven Press, New York, 1978, pp 239-263. 53. Price MT, Olney JW and Cicero TJ. Acute elevations of serum luteinizing hormone induced by kainic acid, N-methylaspartic acid or homocysteic acid. Neuroendocrinology 26, 352-358, 1978. 4. McGeer E, Olney JW and McGeer P (Eds). In: Kainic Acid as a Tool in Neurobiology. Raven Press, New York, 1978. 55. Price MT, Olney JW and Cicero JT. Release of luteinizing hormone induced by N-methylaspartate is blocked by GABA or taurine but not by dopamine antagonists. Neurosci Abst 4, 352, 1978. 56. Fuller T and Olney JW. Naloxone and the effects of systemically administered kainic acid. Neurosci Abst 4, 423, 1978. 57. Olney JW, deGubareff T and Fuller TA. Extreme sensitivity of olfactory cortical neurons to kainic acid toxicity. Neurosci Abst 4, 583, 1978. 58. Price MT, Olney JW, Mitchell MV, Fuller T and Cicero TJ. Luteinizing hormone releasing action of N-methyl aspartate is blocked by GABA or taurine but not by dopamine antagonists. Brain Res 158, 461-465, 1978. 59. Perez VJ, Olney JW, Martin JF and Cannon WO. Minimal tissue concentrations of glutamate required to produce necrosis of hypothalamic neurons. Biol Neonate 35, 17-22, 1979. 60. Olney JW. Excitotoxic amino acids: research applications and safety implications. In: Glutamic Acid: Advances in Biochemistry and Physiology. S Garratini, LJ Filer, MR Kare, WA Reynolds and R Wurtman (Eds), Raven, New York, 1979. 61. Olney JW, deGubareff T and Labruyere J. a-Aminoadipate blocks the neurotoxic action of N-methylaspartate. Life Sci 25, 537-540, 1979. 62. Olney JW, Fuller T and deGubareff T. Acute dendrotoxic changes in the hippocampus of kainate treated rats. Brain Res 176, 91-100, 1979. 63. Olney JW. Excitotoxic amino acids and Huntington's disease. In: Advances of Neurology, Huntington's Disease, Vol. 23. TN Chase, A Wexler, A Barbeau (Eds), Raven, New York, 1979, pp 609-624. 64. Fuller TA and Olney JW. Effects of morphine or naloxone on kainic acid neurotoxicity. Life Sci 24, 1793-1798, 1979. 65. Fuller TA and Olney JW. Morphine enhances and diazepam suppresses the neurotoxicity of systemically administered kainic acid. Neurosci Abst 5, 556, 1979. 66. Price MT, Olney JW, Anglim M, Mitchell V and Buchsbaum S. The LH- releasing action of N-methylaspartate is reversible and is dependent on arcuate hypothalamic neurons. Neurosci Abst 5, 456, 1979. 67. Olney JW, Price MT, Fuller TA, deGubareff T, Anglim M, Labruyere J and Mitchell V. Blockade by a-amino–adipate of the neurotoxic and LH-releasing actions of N-methylaspartate. Neurosci Abst 5, 595, 1979. 68. Price MT, Olney JW, Anglim M, Buchsbaum S and Mitchell V. Cholinomimetics inhibit N-methylaspartate-induced LH release. Endocr Soc Abst 61st Mtg, p 304, 1979. 69. Price MT, Olney JW, Anglim M and Buchsbaum S. Reversible action of N- methylaspartate on gonadotrophin neuroregulation. Brain Res 176, 165-168, 1979. 70. Olney JW and Price MT. GABA inhibition of N-methylaspartate stimulated luteinizing hormone release. Brain Res Bull 4, 703, 1979. 71. Olney JW. Excitotoxic mechanisms of neurotoxicity. Ch 19. In: Experimental and Clinical Neurotoxicology. P Spencer and H Schaumburg (Eds), Williams & Wilkins, Baltimore, 1980, pp 272-294. 72. Olney JW and Price MT. Neuroendocrine interactions of excitatory and inhibitory amino acids. Brain Res Bull 5, Suppl 2, 361-368, 1980. 73. Schwob JE, Fuller T, Price JL and Olney JW. Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: a histological study. Neuroscience 5, 991-1014, 1980. 74. Olney JW. Excitatory neurotoxins as food additives: an evaluation of risk. Neurotoxicology 2, 163-192, 1980. 75. Olney JW, Labruyere J and deGubareff T. Brain damage in mice from voluntary ingestion of glutamate and aspartate. Neurobehav Toxicol 2, 125- 129, 1980. 76. Fuller TA and Olney JW. Kainate neurotoxicity is suppressed by some anticonvulsants but not others. Neurosci Abst 6, 400, 1980. 77. deGubareff T, Olney JW and Collins JF. Stereospecificity of the gliotoxic and anti-neurotoxic actions of alpha aminoadipate. Neurosci Abst 6, 148, 1980. 78. Price MT, Olney JW, Lowry OH and Buchsbaum S. Serum osmolarity and glutamate-induced brain damage. Neurosci Abst 6, 830, 1980. 79. Olney JW, Fuller TA, Collins R and deGubareff T. Dipiperidinoethane mimics kainate convulsions and brain damage. Neurosci Abst 6, 799, 1980. 80. Collins RC, McLean M, Lochman EW, Klunk W and Olney JW. Kainic acid causes limbic seizures. Epilepsia 21, 186, 1980. 81. Collins RC, McLean M and Olney JW. Cerebral metabolic response to systemic kainic acid: 14-C-deoxyglucose studies. Life Sci 27, 855-862, 1980. 82. Olney JW, deGubareff T and Collins JF. Stereospecificity of the gliotoxic and anti-neurotoxic actions of alpha aminoadipate. Neurosci Lett 19, 277-282, 1980. 83. Olney JW, Fuller TA, Collins RC and deGubareff T. Systemic dipiperidinoethane mimics the convulsant and neurotoxic actions of kainic acid. Brain Res 200, 231-235, 1980. 84. Olney JW. Kainic acid and other excitotoxins: a comparative analysis. In: Glutamate as a Neurotransmitter. G DiChiara and GL Gessa (Eds), Raven, New York 1981, pp 375-384. 85. Olney JW and Price MT. Neuroendocrine effects of excitotoxic amino acids. In: Glutamate as a Neurotransmitter. G DiChiara and GL Gessa (Eds), Raven, New York, 1981, pp 423-432. 86. Price MT, Olney JW, Lowry OH and Buchsbaum S. Uptake of exogenous glutamate and aspartate by circumventricular organs but not other regions of brain. J Neurochem 36, 1774-1780, 1981. 87. Price MT, Olney JW and Haft R. Age-related changes in glutamate concentration and synaptosomal glutamate uptake in adult rat striatum. Life Sci 28, 1365-1370, 1981. 88. Olney JW and Sloviter RS. Ultrastructural analysis of hippocampal damage produced by sustained perforant path stimulation in the rat. J Neuropath Exp Neurol 40, 340, 1981. 89. Olney JW. In: Neurosciences Research Program Bulletin, Excitatory Amino Acid Neurotoxins: Selectivity, Specificity, and Mechanisms of Action, Vol 19, No 4, 1981. 90. Olney JW, Fuller TA and deGubareff T. Kainate-like neurotoxicity of folates. Nature 292, 165-167, 1981. 91. Olney JW, Labruyere J, Collins JF and Curry K. D-Aminophosphonovalerate is 100-fold more powerful than D-alpha-aminoadipate in blocking N- methylaspartate neurotoxicity. Brain Res 221, 207-210, 1981. 92. Olney JW, Fuller TA, deGubareff T and Labruyere J. Intrastriatal folic acid mimics the distant but not local brain damaging properties of kainic acid. Neurosci Lett 25, 207-210, 1981. 93. Zucker DK, Wooten GF, Lothman EW and Olney JW. Neuropathological changes associated with intravenous kainic acid. J Neuropathol Exp Neurol 40, 324, 1981. 94. Fuller TA, Olney JW and Conboy VT. Diazepam markedly attenuates the neurotoxicity of folic acid. Neurosci Abst 7, 811, 1981. 95. Price MT, Haft R and Olney JW. Chronic fluphenazine treatment induces changes in glutamate concentrations and glutamate high affinity uptake in adult rat striatum. Neurosci Abst 7, 714, 1981. 96. Olney JW, Fuller TA, deGubareff T and Labruyere J. Folates mimic distinctive features of kainate (but not glutamate) neurotoxicity. Neurosci Abst 7, 810, 1981. 97. deGubareff T, Olney JW and Sloviter RS. Ultrastructural comparison of hippocampal damage produced by electrical stimulation of the perforant path and that induced by kainic acid, folic acid or dipiperidinoethane. Neurosci Abst 7, 590, 1981. 98. Fuller TA and Olney JW. Only certain anticonvulsants protect against kainate neurotoxicity. Neurobehav Toxicol Teratol 3, 355-361, 1981. 99. Collins RC and Olney JW. Focal cortical seizures cause distant thalamic lesions. Science 218, 177-179, 1982. 100. Olney JW. The toxic effects of glutamate and related compounds in the retina and the brain. Retina 2, 341-359, 1982. 101. Fuller TA, Olney JW and Conboy VT. Naloxone blocks morphine enhancement of kainic acid neurotoxicity. Life Sci 3l, 229-233, 1982. 102. Olney JW, Collins JF and deGubareff T. Dipiperidinoethane neurotoxicity clarified. Brain Res 249, 195-197, 1982. 103. Young E, Olney J and Akil H. Delta, but not mu, receptors increase selectively in the thalamus of monosodium glutamate lesioned rats. Presented at International Narcotics Research Club, 1982. 104. Fuller TA, Buchsbaum S and Olney JW. Morphine enhancement of kainate neurotoxicity is opiate receptor specific. Neurosci Abst 8, 1014, 1982. 105. Honchar MP, Olney JW and Sherman WR. Systemic pilocarpine or physostigmine induces seizures and brain damage in lithium-treated rats. Neurosci Abst 8, 773, 1982. 106. Labruyere J, Olney JW and Collins RC. Focal neocortical seizures cause distant lesions within seizure pathways. Neurosci Abst 8, 1012, 1982. 107. Olney JW, deGubareff T and Labruyere J. Cholinergic agents mimic seizure-related aspects of kainate neurotoxicity. Neurosci Abst 8, 773, 1982. 108. Price MT, Pusateri ME, Lowry OH and Olney JW. Entry of exogenous aspartate into circumventricular organs but not other regions of brain. Neurosci Abst 8, 848, 1982. 109. Scallet AC and Olney JW. Combined monosodium glutamate and bipiperidyl mustard lesions prevent naloxone blockade of stress-induced hyperthermia and produce obesity in rats. Neurosci Abst 8, 369, 1982. 110. Tal J, Price MT and Olney JW. Failure of neuroactive amino acids to influence luteinizing hormone release from isolated rat or monkey pituitary. Neurosci Abst 8, 62, 1982. 111. Collins RC, Lothman EW and Olney JW. Status Epilepticus in the limbic system--biochemical and pathological changes. In: Advances in Neurology Vol. 34 - Status Epilepticus. Delgado-Escueta AV, Wasterlain CG, Treiman DM and Porter RJ (Eds), Raven, New York, 1983, pp 277-288. 112. Olney JW, deGubareff T and Labruyere J. Seizure-related brain damage induced by cholinergic agents. Nature 301, 520-522, 1983. 113. Collins RC, Olney JW and Lothman ER. Metabolic and pathological consequences of focal seizures. In: Epilepsy. AA Ward, Jr (Ed), Raven, New York,1983, pp 87-107. 114. Young E, Olney J and Akil H. Selective alterations of opiate receptor subtypes in monosodium glutamate-treated rats. J Neurochem 40, 1558-1564, 1983. 115. Olney JW. Excitotoxins: an overview. In: Excitotoxins. Fuxe K, Roberts P and Schwarcz R (Eds), Macmillan, London, 1983, pp 82-96. 116. Honchar MP, Olney JW and Sherman WR. Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. Science 220, 323- 325, 1983. 117. Tal J, Price MT, Olney JW, Oettinger M and Sharf M. In vitro studies on LH release from rat and monkey anterior pituitaries by neuroactive amino acids. Israel J Med Sci 19, 579, 1983. 118. Olney JW, deGubareff T and Sloviter RS. "Epileptic" brain damage in rats induced by sustained electrical stimulation of the perforant path. II. Ultrastructural analysis of acute hippocampal pathology. Brain Res Bull 10, 699-712, 1983. 119. Tal J, Price MT and Olney JW. Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in either rodents or primates. Brain Res 273, 179-182, 1983. 120. Olney JW and Price MT. Excitotoxic amino acids as neuroendocrine research tools. In: Methods in Enzymology, Vol 103. Conn PM (Ed), Academic Press, New York, 1983, pp 379-393. 121. Olney JW, Honchar MP and Sherman WR. Diazepam prevents lithium- pilocarpine neurotoxicity in rats. Neurosci Abst 9, 401, 1983. 122. Scallet AC and Olney JW. Effects of glutamate and/or bipiperidyl mustard treatment on hypothalamic proopiomelanocortin neurons, food intake, obesity index and blood insulin. Neurosci Abst 9, 281, 1983. 123. Stewart G, Price MT and Olney JW. N-Methylaspartate, a useful excitotoxin for lesioning substantia innominata neurons in the rat. Neurosci Abst 9, 355, 1983. 124. Faris PL, Scallet AC, Olney JW, Della-Fera MA and Baile CA. Behavioral and immunohistochemical analysis of the function of cholecystokinin in the hypothalamic paraventricular nucleus. Neurosci Abst 9, 184, 1983. 125. Price MT, Pusateri ME, Crow SE, Buchsbaum S, Olney JW and Lowry OH. Uptake of exogenous aspartate into circumventricular organs but not other regions of adult mouse brain. J Neurochem 42, 740-744, 1984. 126. Olney JW, Collins RC and Sloviter RS. Excitotoxic mechanisms of epileptic brain damage. In: Advances in Neurology. Delgado-Escueta AV, Ward AA, Woodbury DM and Porter RJ (Eds), Raven, New York, pp 857-877, 1986. 127. Faris PL, McLaughlin CL, Baile CA and Olney JW. Autoimmunization against cholecystokinin (CCK) potentiates morphine analgesia. Fed Proc 43, 935, 1984. 128. Olney JW, Price MT, Samson L and Labruyere J. The ionic basis of excitotoxin-induced neuronal necrosis. Neurosci Abst 10, 24, 1984. 129. Labruyere J, Olney JW and Price MT. Brain damage resulting from intraamygdaloid administration of D-tubocurarine. Neurosci Abst 10, 891, 1984. 130. Samson L, Olney JW, Price MT and Labruyere J. Kynurenate protects against excito toxin-induced neuronal necrosis in chick retina. Neurosci Abst 10, 24, 1984. 131. Price MT, Labruyere J and Olney JW. Does calcium mediate excitotoxin- induced neuronal necrosis? Neurosci Abst 10, 24, 1984. 132. Faris PL, McLaughlin CL, Baile CA and Olney JW. Modulation of morphine analgesia by peripheral cholecystokinin (CCK) and b-endorphin (End). Neurosci Abst 10, 675, 1984. 133. Stewart GR, Hartman BK, Cozzari C and Olney JW. Cholineacetyltransferase immunohistochemical evaluation of an excitotoxin lesion of nucleus basalis. Neurosci Abst 10, 443, 1984. 134. Clifford DB, Olney JW, Zorumski CF. Lithium-pilocarpine seizures: in vitro hippocampal slice studies. Neurosci Abst 10, 552, 1984. 135. Zorumski CF, Collins RC, Olney JW and Clifford DB. Lithium-pilocarpine seizures: in vivo studies. Neurosci Abst 10, 552, 1984. 136. Honchar MP, Price MT, Olney JW and Sherman WR. Effects of lithium and cholinergic agents depend on cholinergic projections to hippocampus and cingulate cortex. Neurosci Abst 10, 1186, 1984. 137. Olney JW. Excitatory transmitters and epilepsy-related brain damage. In: International Review of Neurobiology, Vol 27, Bradley RJ (Ed), 337-362, 1985. 138. Olney JW. Excitotoxic food additives--relevance of animal studies to human safety. Neurobehav Toxicol Teratol 6, 455-462, 1984. 139. Price MT, Olney JW, Samson L and Labruyere J. Calcium influx accompanies but does not cause excitotoxin-induced neuronal necrosis. Brain Res Bull 14, 369-376, 1985. 140. Faris PL, McLaughlin CL, Baile CA, Olney JW and Komisaruk BR. Morphine analgesia potentiated but tolerance not affected by active immunization against cholecystokinin. Science 226, 1215-1217, 1984. 141. Scallet AC and Olney JW. Components of hypothalamic obesity: bipiperidyl-mustard lesions add hyperphagia to monosodium glutamate-induced hyperinsulinemia. Brain Res 374, 380-384, 1986. 142. Olney JW. Aspartate. In: Encyclopedia of Neuroscience. G. Adelman (Ed) Birkhauser, Boston, 1987, p. 80. 143. Olney JW. Glutamate. In: Encyclopedia of Neuroscience. G. Adelman (Ed) Birkhauser, Boston, 1987, pp. 468-470. 144. Olney JW. Food Additives, Excitotoxic. In: Encyclopedia of Neuroscience. G. Adelman (Ed) Birkhauser, Boston, 1987, pp. 436-438. 145. Faris PL, Della-Fera MA, Baile CA and Olney JW. Comparison of the distribution of cholecystokinin and opioid peptides in rat hypothalamus. Fed Proc 44, 1725, 1985. 146. Scallet AC and Olney JW. Developmental damage to rat brain circumventricular organs (CVOs) enhances morphine analgesia in adults. Behav Teratol Soc Mtg, 1985. 147. Della-Fera MA, Miceli MD, Baile CA, Faris P and Olney J. Deficiency of CCK-containing neurons in PVN of hamster brain corresponds with failure of CCK-8 to reduce feeding after injections into the hypothalamic paraventricular nucleus (PVN) of hamsters. Washington Spring Symposium, DC, May 2-5, 1985. 148. Faris PL and Olney JW. Suppression of food intake in rats by microinjection of cholecystokinin (CCK) to the paraventricular nucleus (PVN). Neurosci Abst 11, 39, 1985. 149. Scallet AC, Faris PL, Beinfeld MC and Olney JW. Neurotoxic hypothalamic lesions alter the content of cholecystokinin in anterodorsal hypothalamus and pituitary. Neurosci Abst 11, 54, 1985. 150. Olney JW. Excitotoxic amino acids. News Physiol Sci (NIPS) 1, 19-23, 1986. 151. Rothman SM and Olney JW. Glutamate and the pathophysiology of hypoxic- ischemic brain damage. Ann Neurol 19, 105-111, 1986. 152. Stewart GR, Price M, Olney JW, Hartman BK and Cozzari C. N- Methylaspartate: an effective tool for lesioning basal forebrain cholinergic neurons of the rat. Brain Res 369, 377-382, 1986. 153. Olney JW, Price MT, Samson L and Labruyere J. The role of specific ions in glutamate neurotoxicity. Neurosci Lett 65, 65-71, 1986. 154. Faris PL, Beinfeld MC, Scallet AC, Johannessen JN and Olney JW. Increase in hypothalamic cholecystokinin following acute and chronic morphine. Brain Res 367, 405-407, 1986. 155. Olney JW. Inciting excitotoxic cytocide among central neurons. In: Excitatory Amino Acids and Epilepsy. R Schwarcz and Y Ben-Ari (Eds), Plenum, NY, 1986, pp 631-645. 156. Olney JW, Price MT, Fuller TA, Labruyere J, Samson L, Carpenter M and Mahan K. The anti-excitotoxic effects of certain anesthetics, analgesics and sedative-hypnotics. Neurosci Lett 68, 29-34, 1986. 157. Khachaturian H, Akil H, Brownstein MJ, Olney JW, Voigt KH and Watson SJ. Further characterization of the extra-arcuate alpha-melanocyte stimulating hormone-like material in hypothalamus: biochemical and anatomical studies. Neuropeptides 7, 291 313, 1986. 158. Olney JW, Price MT, Shahid Salles K, Labruyere J, Ryerson R, Mahan K. L-homocysteic acid: a potent endogenous excitotoxin and putative transmitter. Neurosci Abst 12, 380, 1986. 159. Labruyere J, Fuller TA, Olney JW, Price MT, Zorumski C and Clifford D. Phencyclidine and ketamine protect against kainic acid-induced seizures and seizure-related brain damage. Neurosci Abst 12, 344, 1986. 160. Price MT, Olney JW, Fuller TA, Labruyere J, Samson L, Carpenter M and Mahan K. The anti-excitotoxic effects of certain anesthetics, analgesics, and sedative-hypnotics. Neurosci Abst 12, 342, 1986. 161. Shahid Salles K, Price MT, Ryerson R, Ray J and Olney JW. Dissociative anesthetics and sigma opiates powerfully block NMA neurotoxicity but do not bind at the NMA receptor. Neurosci Abst 12, 60, 1986. 162. Stewart GR, Carnes KM, Olney JW, Price JL and Fuller TA. A basal forebrain cholinergic projection to the nucleus of the lateral olfactory tract. Neurosci Abst 12, 355, 1986. 163. Prewitt D, Stewart GR, Kalmbach S, Olney JW, Hartman BK, Cozzari C. Neuronal ectopias and the basal forebrain cholinergic system of the rodent. Neurosci Abst 12, 443, 1986. 164. Steinmen JL, Faris PL and Olney JW. Further evidence for vagal involvement in the periheral peptidergic modulation of nociception. Neurosci Abst 12, 1490, 1986. 165. Faris PL, Kettinger JP and Olney JW. Vagotomy attenuates the increase in feeding following microinjections of cholecystokinin-antiserum to the hypothalamic paraventricular nucleus. Neurosci Abst 12, 595, 1986. 166. Clifford DB, Olney JW, Collins RC, Maniotis A, Zorumski CF. Lithium- pilocarpine and pilocarpine induced seizures: metabolism and neuropathology. Neurosci Abst 12, 696, 1986. 167. Olney JW. Excitotoxins and selective neuronal death. In: CIBA Foundation Symposium 126, John Wiley and Sons Limited, Chichester, 1987. 168. Olney JW. Excitatory amino acids and neuropsychiatric disorders. In: Excitatory Amino Acid Transmission. T.P. Hicks, D. Lodge and H. McLennon (Eds), Alan R. Liss, Inc., N.Y., pp 217-224, 1986. 169. Olney JW. Excitatory transmitters and neuropsychiatric disorders. In: Neuronal Control of Bodily Function: Neurobiology of Amino Acids, Peptides and Trophic Factors. Ferrendelli JA, Collins RC, Johnson EM (Eds), Kluwer Acad Pubs, Dordrecht, Netherlands, 51-61, 1988. 170. Olney JW, Price MT, Shahid Salles K, Labruyere J, Ryerson R, Mahan K, Frierdich G, and Samson L. L-homocysteic acid: An endogenous excitotoxic ligand of the NMDA receptor. Brain Res Bull 19, 597-602 1987. 171. Clifford DB, Olney JW, Maniotis A, Collins RC and Zorumski CF. The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures. Neurosci 23, 953-968, 1987. 172. Rothman SM and Olney JW. Excitotoxicity and the NMDA receptor. TINS 10, 299-302, 1987. 173. Olney J, Price M, Shahid Salles K, Labruyere J, Frierdich G. MK-801 powerfully protects against N-methyl aspartate neurotoxicity. Eur J Pharmacol 141, 357-361 1987. 174. Olney JW. Endogenous Excitotoxins and Neuropathological Disorders. In: Excitatory Amino Acids in Health and Disease. D. Lodge (Ed), John Wiley & Sons Ltd., England, 1988, pp 337-351. 175. Olney JW, Price MT, Labruyere J, Silverman E, Mueller M. Comparative efficacy of various agents in preventing glutamate-induced or ischemic neuronal degeneration in chick retina. Neurosci Abst 13, 1030, 1987. 176. Price MT, Olney JW, Shahid Salles K., Labruyere J and Frierdich G. MK-801 powerfully protects against N-methyl aspartate neurotoxicity. Neurosci Abst 13, 1556, 1987. 177. Fuller TA, Lawrence JJ and Olney JW. Blockade of N-methylaspartate- induced arcuate nucleus damage by PCP, MK-801 and related compounds. Neurosci Abst 13, 1475, 1987. 178. Clifford DB, Benz A, Olney JW and Zorumski CF. MK-801 prevents thalamic damage induced by focal cortical seizures. Neurosci Abst 13, 1077, 1987. 179. Wozniak DF, Stewart GR, Finger S and Olney JW. Comparison of behavioral effects of nucleus basalis lesions versus sensorimotor cortex ablation. Neurosci Abst 13, 1065 1987. 180. Stewart GR, Wozniak DF, Finger S, Olney JW and Cozzari C. Behavioral consequences of N-methyl aspartate-induced destruction of basal forebrain cholinergic neurons. Neurosci Abst 13, 1065, 1987. 181. Olney JM, Gray GE, Frierdich G, Shahid Salles K, Labruyere J, Price MT and Olney JW. Hypoxia-ischemia causes glutamate-like neuropathological changes in infant rat brain. Neurosci Abst 13, 1553, 1987. 182. Lawrence JJ, Fuller TA and Olney JW. MK-801 and PCP protect against ischemic neuronal degeneration in the gerbil hippocampus. Neurosci Abst 13, 1079, 1987. 183. Pullan LM, Olney JW, Price MT, Compton RP, Hood WF, Michel J and Monahan JB. Excitatory amino acid receptor potency and subclass specificity of sulfur-containing amino acids. J Neurochem 49, 1301-1307, 1987. 184. Scallet AC, Faris PL, Beinfeld MC and Olney JW. Hypothalamic neurotoxins alter the content of immuno- reactive cholecystokinin in pituitary. Brain Res 407, 390-393, 1987. 185. Olney JW. Excitotoxic food additives: functional teratological aspects. In: Progress In Brain Res. Boer, Feenstra, Mirmiran, Swaab, Van Haaren (Eds), Elsevier, The Netherlands, 1988, pp 283-294. 86. Clifford DB, Olney JW, Benz AM, Fuller TA and Zorumski CF. Ketamine, phencyclidine and MK-801 protect against kainic acid induced seizure-related brain damage. Epilepsia 31:382-390, 1990. 187. Stewart GR, Zorumski CF, Price MT and Olney JW. Domoic acid: A dementia-inducing excitotoxic food poison with kainic acid receptor specificity. Exp Neurol 110, 127-138, 1990. 188. Olney JW, Price MT, Labruyere J, Shahid Salles K, Frierdich G, Mueller M and Silverman E. Anti-parkinsonian agents are phencyclidine agonists and N-methyl aspartate antagonists. Eur J Pharmacol 142, 319-320, 1987. 189. Wozniak DF, Stewart GR, Finger S, Olney JW and Cozzari C. Basal forebrain lesions impair tactile discrimination and working memory. Neurobiol Aging 10, 173-179, 1989. 190. Olney JW. Revelations in Excitotoxicology: What next? Neurochemistry International 12, 12, 1988. 191. Ikonomidou C, Frierdich G, Labruyere J, Price MT and Olney JW. Hypobaric-ischemic conditions cause glutamate-like damage in infant rat brain. Neurochemistry International 12, 39, 1988. 192. Olney JW. Revelations in excitotoxicology: What next? In: Frontiers in Excitatory Amino Acid Research. E.A. Cavalheiro, J. Lehmann, L. Turski, (Eds), Alan R. Liss, Inc., N.Y., pp 589-596, 1988. 193. Ikonomidou C, Frierdich G, Shahid Salles K, Labruyere J, Price MT and Olney JW. Glutamate-like damage in infant rat brain produced by hypobaric- ischemic conditions. In: Frontiers in Excitatory Amino Acid Research. E.A. Cavalheiro, J. Lehmann, L. Turski, (Eds), Alan R. Liss, Inc., N.Y. pp 657-660, 1988. 194. Olney JW, Ikonomidou C, Mosinger J, Shahid Salles K and Frierdich G. Role of the N-methyl aspartate receptor in developmental psychoneuropathology. Neurosci Abst 14, 417, 1988. 195. Price MT, Honore T, Mueller ME, Labruyere J, Silverman E and Olney JW. CNQX potently and selectively blocks kainate excitotoxicity in the chick embryo retina. Neurosci Abst 14, 418, 1988. 196. Ikonomidou C, Mosinger J, Shahid Salles K, Labruyere J and Olney JW. Parallel patterns of hypersensitivity to NMA toxicity and hypobaric/ischemic damage in developing rat brain. Neurosci Abst 14, 501, 1988. 197. Stewart GR, Mueller ME, Price MT and Olney JW. Neuroplastic potential of cholinergic neurons that project to the basolateral amygdala. Neurosci Abst 14, 1222, 1988. 198. Shahid Salles K, Frierdich G, Price MT and Olney JW. Changes in 3H- QNB and 3H-glutamate binding in rat brain following persistent seizures induced by lithium/pilocarpine treatment. Neurosci Abst 14, 1329, 1988. 199. Mosinger JL, Price MT, Labruyere J, Mueller ME, Silverman E and Olney JW. Glutamate blocks kainate neurotoxicity in the chick embryo retina. Neurosci Abst 14, 417, 1988. 200. Wozniak DF, Olney JW and Kettinger L III. Effects of MK-801 on memory retention in the rat. Neurosci Abst 14, 941, 1988. 201. Clifford DB, Benz A, Olney JW and Zorumski CF. MK-801 prevents seizure related brain damage from pilocarpine and lithium-pilocarpine epidural well induced seizures. Neurosci Abst 14, 863, 1988. 202. Ikonomidou C, Price MT, Mosinger JL, Frierdich G, Labruyere J, Shahid Salles K and Olney JW. Hypobaric-ischemic conditions produce glutamate-like cytopathology in infant rat brain. J Neurosci 9, 1693-1700, 1989. 203. Olney JW, Ikonomidou C, Mosinger JL and Frierdich G. MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain. J Neurosci 9, 1701-1704, 1989. 204. Olney JW. Excitatory amino acids and neuropsychiatric disorders. Biol Psychiatry 26, 505-525, 1989. 205. Olney JW. Excitotoxicity and NMDA receptors. Drug Dev Res 17, 299- 319, 1989. 206. Ikonomidou C, Mosinger JL and Olney JW. Hypothermia enhances protective effect of MK-801 against hypoxic/ischemic brain damage in infant rats. Brain Res 487, 184-187, 1989. 207. Ikonomidou C, Mosinger JL, Shahid Salles K, Labruyere J and Olney JW. Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-Methyl-Aspartate neurotoxicity. J Neurosci 9, 2809-2818, 1989. 208. Wozniak DF, Stewart GR, Finger S and Olney JW. Comparison of behavioral effects of nucleus basalis magnocellularis lesions and somatosensory cortex ablation in the rat. Neuroscience 32, 685-700, 1989. 209. Ikonomidou C, Mosinger JL and Olney JW. Protective effect of low-grade hypothermia against hypoxic/ischemic brain damage in infant rats. 12th Biannual Meeting Int Soc Neurochem, Algrave, Portugal, April 23-28, 1989. J Neurochem Suppl, 1989. 210. Mosinger JL and Olney JW. Photothrombosis-induced ischemic neuronal degeneration in the rat retina. Invest Ophthalmol & Vis Sci Suppl 30, 136, 1989. 211. Olney JW, Labruyere J and Price, MT. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244, 1360-1362. 1989. 212. Olney JW, Labruyere J and Price MT. Neurocytotoxicity of phencyclidine and MK-801. Biol Psychiatry Abstr 25, 133A, 1989. 213. Steinman JL, Faris PL, Mann PE, Olney JW, Komisaruk BR, Willis WD and Bodnar RJ. Antagonism of morphine analgesia by nonopioid cold-water swim analgesia: Direct evidence for collateral inhibition. Neurosci Biobehav Rev 14, 1-7, 1990. 214. Olney JW and Price MT. Excitotoxic amino acids as neuroendocrine research tools. In: Neuroendo-crine Peptide Methodology. P. Michael Conn (Ed), Academic Press, Inc., San Diego, Cal., 1989, pp 891-905. 215. Mosinger JL and Olney JW. Photothrombosis-induced ischemic neuronal degeneration in the rat retina. Exp Neurol 105, 110-113, 1989. 216. Clifford DB, Zorumski CF and Olney JW. Ketamine and MK-801 prevent degeneration of thalamic neurons induced by focal cortical seizures. Exp Neurol 105, 272-279, 1989. 217. Olney JW. Glutamate, a neurotoxic transmitter. J Child Neurol 4, 218- 226, 1989. 218. Olney JW and Ikonomidou C. Endogenous excitotoxins and perinatal hypoxic/ischemic brain damage. Proceedings 6th Capo Boi Conference on Neuroscience, Cagliari, Italy. June 3, 1989. 219. Olney JW. Excitotoxin-mediated neuron death in youth and old age. In: Progress in Brain Research, Vol. 86. PD Coleman, GA Higgins and CH Phelps, (Eds), Elsevier Science Pubs BV, Amsterdam, The Netherlands, 1990, pp 37-51. 220. Olney JW, Labruyere J and Price MT. L-cysteine, an endogenous NMDA- mimetic excitotoxin that induces generalized ischemia-like neonatal or fetal brain damage. Neurosci Abst 15, 480, 1989. 221. Price MT, Stewart GR and Olney JW. Procyclidine protects against soman neurotoxicity, even when administered after onset of convulsions. Neurosci Abst 15, 1349, 1989. 222. Mosinger JL and Olney JW. Combined treatment with MK-801 and CNQX prevents ischemic neuronal degeneration in the in vivo rat retina. Neurosci Abst 15, 45, 1989. 223. Labruyere J, Price MT and Olney JW. NMDA antagonists induce pathomorphological changes in cerebrocortical neurons. Neurosci Abst 15, 761, 1989. 224. Stewart GR, Wozniak DF, Schmidt RE and Olney JW. Calcification of the globus pallidus following excitotoxic destruction of the nucleus basalis. Neurosci Abst 15, 1043, 1989. 225. Olney JW. Excitotoxic Lesions. In: Selective Lesioning in the Nervous System, Neurosci Short Course Syllabus, 1-12, 1989. 226. Olney JW. Excitotoxicity: An Overview. Proceedings of a symposium on domoic acid toxicity held at the Health Protection Branch, Health and Welfare Canada, April 11-12, 1989. In: Canada Diseases Weekly Report Supplement, Volume 16S1E, September 1990, pp 47-58. 227. Olney JW and Ikonomidou C. Extreme sensitivity to excitotoxic brain damage in youth and old age. 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Neurosci Abst 15, 767, 1989. 232. Olney JW, Zorumski CF, Stewart GR, Price MT, Wang G and Labruyere J. Excitotoxicity of L-DOPA and 6-OH-DOPA: Implications for Parkinson's and Huntington's Diseases. Exp Neurol 108, 269-272, 1990. 233. Olney JW, Zorumski C, Price MT and Labruyere J. L-Cysteine, a bicarbonate-sensitive endogenous excitotoxin. Science 248, 596-599, 1990. 234. Olney JW. Memoirs of an Excitotoxicologist. In: The Neurosciences: Paths of Discovery, II. F Samson and G Adelman (Eds), Birkhäuser Boston Inc, Cambridge, MA, 1992; pp 169-187. 235. Olney JW. Excitotoxicity: An overview. Biol Psychiatry Abst 27, 90A, 1990. 236. Olney JW, Labruyere J and Price MT. Phencyclidine, dizocilpine and cerebrocortical neurons: Technical Comments. Science 247, 221, 1990. 237. Olney JW, Price MT, Zorumski CF and Clifford DB. Cholinotoxic syndromes: Mechanisms and protection. Workshop on convulsions and related brain damage induced by organophosphorus agents, Aberdeen Proving Ground, MD, February 1-2, 1990, pp 147-162. 238. Olney JW. Phencyclidine neurotoxicity. In: Neuroscience Year: Supplement 2, Encyclopedia of Neuroscience, 1992, pp 128-129. 239. Olney JW and Ikonomidou C. Excitotoxic mechanisms operative in youth and old age. In: Neurobiology of the NMDA receptor: From chemistry to the clinic. AP Kozikowski and G Barrionuevo (Eds), VCH Publishers, NY, 1991, pp 187-202. 240. Olney JW. Response to Letter to the Editor. Excitatory amino acid hypothesis of schizophrenia. Biol Psychiatry 28, 553-554, 1990. 241. Olney JW, Labruyere J, Wang GJ, Price MT. Anticholinergics prevent neurotoxic side effects of NMDA antagonists. Neurosci Abst 16, 1122, 1990 242. Price MT and Olney JW. Excitatory amino acid antagonists as anti- emetics. Neurosc Abst 16, 377, 1990. 243. Wozniak DF, Stewart GR, Fry B, Kettinger L and Olney JW. Kainate neurotoxicity in aged rats: A model for studying domoate dementia in aged humans. Neurosci Abst 16, 197, 1990. 244. Stewart GR, Zorumski CF, Price MT and Olney JW. Domoic Acid: A dementia-inducing excitotoxic food poison with kainic acid receptor specificity. Neurosci Abst 16, 1122, 1990. 245. Bai HY, Xiao H, Price MT, Olney JW. Protection against ischemic neuronal degeneration in vitro or in vivo by honghua, an anti-excitotoxic chinese herbal medicine. Neurosci Abst 16, 275, 1990. 246. Wang GJ, Labruyere J, Price MT, Olney JW. Extreme sensitivity of infant animals to glutamate toxicity: Role of NMDA receptors. Neurosci Abst 16, 198, 1990. 247. Olney JW. Excitotoxins and neurological diseases. In: Proceedings of the XIth International Congress of Neuropathology "Neuropathology" Supplement 4. XIth ICN Organizing Committee (Eds), The Japanese Society of Neuropathology, 1991, pp 209-214. 248. Olney JW. Trying to get glutamate out of baby food. 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Science 251,1619-1620, 1991. 253. Zorumski CF and Olney JW. Environmental excitotoxins and neurodegenerative disorders. In: Clinics in Applied Nutrition, Volume 1, Issue 2. R Chernoff (Ed), Andover Med Pub, Inc, 1991, pp 61-70. 254. Olney JW. Neurology. In: Academic Press Dictionary of Science and Technology. C Morris (Ed), Harcourt Brace Inc, Pubs 1992, 1460. 255. Sesma MA, Price MT and Olney JW. Sensitivity of retinal ganglion cell subtypes to specific excitotoxins. Investigative Ophthalmology and Visual Science 32: Suppl, ARVO Abstract 1263 1991. 256. Zorumski CF and Olney JW. Excitotoxicity and neurodegenerative disorders. In: Emerging Strategies in Neuroprotection. PJ Marangos and H Lal (Eds), Birkhäuser Boston, Inc., 1992, pp 326-343. 257. Olney JW, Labruyere J, Wang G, Wozniak DF, Price MT and Sesma MA. NMDA antagonist neurotoxicity: Mechanism and prevention. Science 254:1515-1518, 1991. 258. Olney, JW. Glutamatergic mechanisms in neuropsychiatry. In: Novel Antipsychotic Drugs. HY Meltzer (Ed), Raven Press, NY, 1992, 155-169. 259. Olney, JW. Excitotoxicity: Relevance to brain disorders in both youth and old age. In: Biological Psychiatry, Volume 2. G Racagni, N Brunello and T Fukuda (Eds), Elsevier Science Publishers B.V., The Netherlands, 1991, 765-768. 260. Zorumski CF and Olney JW. Acute and chronic neurodegenerative disorders produced by dietary excitotoxins. In: The Vulnerable Brain and Environmenal Risks Vol 2: Toxins in Food. RL Isaacson and KF Jensen (Eds), Plenum Press, NY, 1992, pp 273-292. 261. Olney JW, Sesma MA, Labruyere J, Price MT. New evidence linking PCP neurotoxicity in rats with PCP psychosis in humans. Neurosci Abst 17, 190, 1991. 262. Price MT, Wozniak DF, Sun S, Olney JW. Quisqualate injection into the nucleus basalis magnocellularis induces seizure-related brain damage. Neurosci Abst 17, 1065, 1991. 263. Wozniak DF, Stewart GR, Sun S, Olney JW. Sensitivity of basal forebrain somatostatinergic neurons to N-methyl aspartate neurotoxicity. Neurosci Abst 17, 1066, 1991. 264. Sesma MA, Price MT, Olney JW. Heat shock protein (HSP 72) response to NMDA antagonists is blocked by anticholinergics or GABAmimetics. Neurosci Abst 17, 254, 1991. 265. Romano C, Price MT, Bai HY, Olney JW. Intravitreal injection of glucose protects against ischemic degeneration of retinal neurons. Neurosci Abst 17, 1078 1991. 266. Wang GJ, Qin YQ, Price MT, Olney JW. Homocysteate, kainate and AMPA induce spinal cord lesions when administered subcutaneously to infant rats. Neurosci Abst 17, 787, 1991. 267. Tizzano JP, Schoepp DD, Price MT and Olney JW. Widespread degeneration induced in the developing rodent CNS by D,L-2-amino-3- phosphonopropionate (AP3). Neurosci Abst 17, 70, 1991. 268. Wozniak DF, Stewart GR, Miller JP and Olney JW. Age-related sensitivity to kainate neurotoxicity. Exp Neurol 114, 250-253, 1991. 269. Stewart GR, Olney JW, Pathikonda M and Snider WD. Excitotoxicity in the embryonic chick spinal cord. Ann Neurol 30: 758-766, 1991. 270. Olney, JW. Excitotoxins and neurologic diseases. Alfred Benzon Symposium No. 32. In: Drug Research Related to Neuroactive Amino Acids. A Schousboe, NH Diemer, H Kofod (Eds), Munksgaard, Copenhagen, 1992, pp 257- 270. 271. Olney JW, Price MT, Zorumski CF and Yamada K. Neurotoxicological evidence for a novel benzo-diazepine site within the non-NMDA glutamate receptor complex. Soc Neurosci Abst 18, 757, 1992. 272. Price MT, Ikonomidou C, Labruyere J, Izumi Y and Olney JW. Neurotoxicity linked to the glutamate metabotropic receptor. Soc Neurosci Abst 18, 83, 1992. 273. Wozniak DF, McEwen M, Brosnan-Watters G and Olney, JW. MK-801- induced impairment on a memory task is counteracted by scopolamine. Soc Neurosci Abst 18, 1153, 1992. 274. Farber NB, Price MT, Labruyere J, Fuller TA, Olney JW. Age dependency of NMDA antagonist neurotoxicity. Soc Neurosci Abst 18, 1148, 1992. 275. Benz AM, Izumi Y, Clifford DB, Zorumski CF, Olney JW. Neurotoxic effects of sodium nitroprusside in rat hippocampal slices. Soc Neurosci Abst 18, 645, 1992. 276. Zorumski CF, Yamada K, Mennerick S, Olney JW. Electrophysiological evidence for a novel benzodiazepine site within the non-NMDA glutamate receptor complex. Soc Neurosci Abst 18, 757, 1992. 277. Fink-Jensen A, Judge ME, Hansen JB, Jacobsen P, Turski L, Olney J, Honore T. Inhibition of cisplatin-induced emesis in ferrets by the non-NMDA receptor antagonists NBQX and CNQX. Neurosci Lett 137:173-177, 1992. 278. Olney JW, Sesma MA, Wozniak DF. Glutamatergic, cholinergic, and GABAergic systems in posterior cingulate cortex: Interactions and possible mechanisms of limbic system disease. In: Neurobiology of Cingulate Cortex and Limbic Thalamus. BA Vogt and M Gabriel (Eds), Birkhäuser, Boston, 1993, pp 557-580. 279. Romano C, Price M, Bai H-Y, Olney JW: Neuroprotectants in Honghua: Glucose attenuates retinal ischemic damage. Invest Ophthalmol Vis Sci 34,72-80, 1993. 280. Olney JW. Excitatory transmitter neurotoxicity. Neurobiol Aging 15:259-260, 1994. 281. Olney JW. Excitotoxicity. In: Principles of Neurotoxicology. LW Chang (Ed), Marcel Dekker, Inc, NY, 1994, pp 495-523. 282. Olney JW. Role of excitotoxins in developmental neuropathology. Acta Path Microbiol Immunol Scand, 101/Suppl 40: 103-112, 1993. 283. Zorumski CF, Yamada KA, Price MT, Olney JW. A benzodiazepine recognition site associated with the non-NMDA glutamate receptor. Neuron 10, 61-67, 1993. 284. Lin C, Olney JW, Price MT, Romano C. The effect of ocular hypertension-induced ischemia on the rat retina: An immunocytochemical study. Invest Ophthalmol Vis Sci 34,1431, 1993. 285. Romano C, Price M, Olney JW. Delayed excitotoxic neurodegeneration induced by glutamate, kainate, and NMDA in isolated retina. 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Farber NB, Hanslick J, Kirby C, McWilliams L, Olney, JW. Serotonergic agents that activate 5HT2A receptors prevent NMDA antagonist neurotoxicity. Neuropsychopharmacology 18(1), 57-62, 1998. 382. Olney JW, Wozniak DF, Farber NB. Excitotoxic neurodegeneration in Alzheimer's disease: New hypothesis and new therapeutic strategies. Arch Neurol 54 (10), 1234-1240, 1997. 383. Olney JW, Wozniak DF, Nardi A, Powell S, Jevtovic-Todorovic V. Clonidine potentiates the neuropathic pain relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effects. Soc Neurosci Abst, 23, 2308, 1997. 384. Farber NB, Kim SH, Olney JW. Costimulation of muscarinic and non- NMDA glutamate receptors reproduces NMDA antagonist neurotoxicity. Soc Neurosci Abst, 23, 2308, 1997. 385. Wozniak DF, Jevtovic-Todorovic V, Powell S, Olney JW. Propofol protects cerebrocortical neurons against the cell killing action of MK-801. Soc Neurosci Abst, 23, 2309, 1997. 386. Kim SH, Farber NB, Price MT, Olney JW. Clonidine suppresses MK801- induced acetylcholine release in rat posterior cingulate cortex: in vivo microdialysis study. Soc Neurosci Abst, 23, 2308, 1997. 387. Dikranian K, Wozniak DF, Ishimaru MJ, Price MT, Nardi A, Olney JW. Ultrastructural evaluation of disseminated lesions induced by MK-801. Soc Neurosci Abst, 23, 2309, 1997. 388. Chen Q, Olney J, Almli T, Romano C. Fenamates protect neurons against ischemic and excitotoxic injury. Soc Neurosci Abst, 23, 1921, 1997. 389. Jevtovic-Todorovic V, Olney JW. Nitrous oxide: general anesthetic, NMDA antagonist, neuroprotectant and neurotoxin. Soc Neurosci Abst, 23, 2309, 1997. 390. Ishimaru MJ, Ikonomidou C, Dikranian K, Olney JW. CNS apoptosis: how shall it be defined and recognized? Soc Neurosci Abst, 23, 895, 1997. 391. Jevtovic-Todorovic V, Wozniak DF, Nardi A, Powell S, Olney JW. Clonidine potentiates the neuropathic pain relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effects. 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